Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation

EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR for regulation of gene transcription and DNA repair. We fail to detect EGFR endocytosis or nuclear transpo...

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Detalles Bibliográficos
Autores principales: Tomas, Alejandra, Jones, Sylwia, Vaughan, Simon O., Hochhauser, Daniel, Futter, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558270/
https://www.ncbi.nlm.nih.gov/pubmed/28646091
http://dx.doi.org/10.1242/jcs.202358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558270/
https://www.ncbi.nlm.nih.gov/pubmed/28646091
http://dx.doi.org/10.1242/jcs.202358

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