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The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation

OBJECTIVE: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks’ gestation and trisomy 21 and adverse perinatal outcomes. MATERIALS AND METHODS: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus...

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Autores principales: Karakoç, Gökhan, Yavuz, And, Eriş Yalçın, Serenat, Akkurt, Mehmet Özgür, Danışman, Nuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558314/
https://www.ncbi.nlm.nih.gov/pubmed/28913131
http://dx.doi.org/10.4274/tjod.61482
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author Karakoç, Gökhan
Yavuz, And
Eriş Yalçın, Serenat
Akkurt, Mehmet Özgür
Danışman, Nuri
author_facet Karakoç, Gökhan
Yavuz, And
Eriş Yalçın, Serenat
Akkurt, Mehmet Özgür
Danışman, Nuri
author_sort Karakoç, Gökhan
collection PubMed
description OBJECTIVE: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks’ gestation and trisomy 21 and adverse perinatal outcomes. MATERIALS AND METHODS: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD) measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results. These women were followed up for enrollment of subsequent data about perinatal outcomes. RESULTS: In 13 of 174 cases, Doppler studies indicated a reversed a-wave in the ductus venosus. Of these fetuses, 3 were diagnosed as having trisomy 21 after amniocentesis, which related to 60% (3 of 5 fetuses) of all fetuses with trisomy 21. The pregnant women with reversed a-wave in DVD also had an increased rate of preeclampsia (15%) and gestational diabetes mellitus (GDM) (23%) in late pregnancy. CONCLUSION: Reversed a-wave in ductus venosus between 16-20 weeks’ gestation is associated with increased risk of trisomy 21, preeclampsia, and GDM. If further prospective studies confirm its utility, DVD interrogation for trisomy 21 may be extended until 20 weeks’ gestation.
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spelling pubmed-55583142017-09-14 The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation Karakoç, Gökhan Yavuz, And Eriş Yalçın, Serenat Akkurt, Mehmet Özgür Danışman, Nuri Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks’ gestation and trisomy 21 and adverse perinatal outcomes. MATERIALS AND METHODS: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD) measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results. These women were followed up for enrollment of subsequent data about perinatal outcomes. RESULTS: In 13 of 174 cases, Doppler studies indicated a reversed a-wave in the ductus venosus. Of these fetuses, 3 were diagnosed as having trisomy 21 after amniocentesis, which related to 60% (3 of 5 fetuses) of all fetuses with trisomy 21. The pregnant women with reversed a-wave in DVD also had an increased rate of preeclampsia (15%) and gestational diabetes mellitus (GDM) (23%) in late pregnancy. CONCLUSION: Reversed a-wave in ductus venosus between 16-20 weeks’ gestation is associated with increased risk of trisomy 21, preeclampsia, and GDM. If further prospective studies confirm its utility, DVD interrogation for trisomy 21 may be extended until 20 weeks’ gestation. Galenos Publishing 2017-03 2017-03-15 /pmc/articles/PMC5558314/ /pubmed/28913131 http://dx.doi.org/10.4274/tjod.61482 Text en © Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Karakoç, Gökhan
Yavuz, And
Eriş Yalçın, Serenat
Akkurt, Mehmet Özgür
Danışman, Nuri
The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title_full The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title_fullStr The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title_full_unstemmed The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title_short The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
title_sort significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558314/
https://www.ncbi.nlm.nih.gov/pubmed/28913131
http://dx.doi.org/10.4274/tjod.61482
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