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The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles

OBJECTIVE: To assess the relationship between the estrogen-progesterone alterations before and after ovulation trigger and treatment success in intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Two hundred fifty-one women with infertility underwent ovulation induction followed by IUI. F...

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Autores principales: Kutlu, Tayfun, Özkaya, Enis, Şanverdi, İlhan, Devranoğlu, Belgin, İpekçi, Cansu, Konukçu, Birsen, Şahin, Yavuz, Karateke, Ateş
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558338/
https://www.ncbi.nlm.nih.gov/pubmed/28913092
http://dx.doi.org/10.4274/tjod.45656
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author Kutlu, Tayfun
Özkaya, Enis
Şanverdi, İlhan
Devranoğlu, Belgin
İpekçi, Cansu
Konukçu, Birsen
Şahin, Yavuz
Karateke, Ateş
author_facet Kutlu, Tayfun
Özkaya, Enis
Şanverdi, İlhan
Devranoğlu, Belgin
İpekçi, Cansu
Konukçu, Birsen
Şahin, Yavuz
Karateke, Ateş
author_sort Kutlu, Tayfun
collection PubMed
description OBJECTIVE: To assess the relationship between the estrogen-progesterone alterations before and after ovulation trigger and treatment success in intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Two hundred fifty-one women with infertility underwent ovulation induction followed by IUI. For all subjects, estradiol and progesterone concentrations were evaluated on the trigger and IUI day. The results were analyzed to assess the relationship between hormone levels and positive pregnancy test. RESULTS: There were 34 women with a positive pregnancy test following controlled ovarian stimulation and IUI cycle. Estradiol and progesterone levels on the trigger day and the day of IUI were compared within groups with and without positive pregnancy tests. The comparison revealed significantly increased levels of progesterone after trigger in both groups; however, although there were estradiol level drops in both groups, the drop in the group with negative pregnancy tests was statistically significant. CONCLUSION: Significant drops in estradiol concentrations after ovulation trigger are associated with IUI cycle treatment failure.
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spelling pubmed-55583382017-09-14 The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles Kutlu, Tayfun Özkaya, Enis Şanverdi, İlhan Devranoğlu, Belgin İpekçi, Cansu Konukçu, Birsen Şahin, Yavuz Karateke, Ateş Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: To assess the relationship between the estrogen-progesterone alterations before and after ovulation trigger and treatment success in intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Two hundred fifty-one women with infertility underwent ovulation induction followed by IUI. For all subjects, estradiol and progesterone concentrations were evaluated on the trigger and IUI day. The results were analyzed to assess the relationship between hormone levels and positive pregnancy test. RESULTS: There were 34 women with a positive pregnancy test following controlled ovarian stimulation and IUI cycle. Estradiol and progesterone levels on the trigger day and the day of IUI were compared within groups with and without positive pregnancy tests. The comparison revealed significantly increased levels of progesterone after trigger in both groups; however, although there were estradiol level drops in both groups, the drop in the group with negative pregnancy tests was statistically significant. CONCLUSION: Significant drops in estradiol concentrations after ovulation trigger are associated with IUI cycle treatment failure. Galenos Publishing 2016-06 2016-06-15 /pmc/articles/PMC5558338/ /pubmed/28913092 http://dx.doi.org/10.4274/tjod.45656 Text en © Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Kutlu, Tayfun
Özkaya, Enis
Şanverdi, İlhan
Devranoğlu, Belgin
İpekçi, Cansu
Konukçu, Birsen
Şahin, Yavuz
Karateke, Ateş
The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title_full The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title_fullStr The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title_full_unstemmed The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title_short The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
title_sort relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558338/
https://www.ncbi.nlm.nih.gov/pubmed/28913092
http://dx.doi.org/10.4274/tjod.45656
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