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The effect of first chromosome long arm duplication on survival of endometrial carcinoma

OBJECTIVE: The aim of this study is to investigate the effect of first chromosome long arm duplication (dup(1q)) in cases with endometrial carcinoma detected with array based comperative genomic hybridization (aCGH) on survival from the cancer. MATERIALS AND METHODS: A total of 53 patients with the...

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Autores principales: Sever, Erman, Doğer, Emek, Çakıroğlu, Yiğit, Sünnetçi, Deniz, Çine, Naci, Savlı, Hakan, Yücesoy, İzzet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558362/
https://www.ncbi.nlm.nih.gov/pubmed/28913021
http://dx.doi.org/10.4274/tjod.05617
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author Sever, Erman
Doğer, Emek
Çakıroğlu, Yiğit
Sünnetçi, Deniz
Çine, Naci
Savlı, Hakan
Yücesoy, İzzet
author_facet Sever, Erman
Doğer, Emek
Çakıroğlu, Yiğit
Sünnetçi, Deniz
Çine, Naci
Savlı, Hakan
Yücesoy, İzzet
author_sort Sever, Erman
collection PubMed
description OBJECTIVE: The aim of this study is to investigate the effect of first chromosome long arm duplication (dup(1q)) in cases with endometrial carcinoma detected with array based comperative genomic hybridization (aCGH) on survival from the cancer. MATERIALS AND METHODS: A total of 53 patients with the diagnosis of endometrial carcinom due to endometrial biopsy and who have been operated for this reason have been allocated in the study. Frozen section biopsy and staging surgery have been performed for all the cases. Samples obtained from the tumoral mass have been investigated for chromosomal aberrations with aCGH method. Kaplan-Meier and Cox-regression analysis have been performed for survival analysis. RESULTS: Among 53 cases with endometrial carcinomas, dup(1q) was diagnosed in 14 (26.4%) of the cases. For the patient group that has been followed-up for 24 months (3-33 months), dup(1q) (p=.01), optimal cytoreduction (p<.001), lymph node positivity (p=.006), tumor stage >1 (p=.006) and presence of high risk tumor were the factors that were associated with survival. Cox-regression analysis has revealed that optimal cytoreduction was the most important prognostic factor (p=.02). CONCLUSION: Presence of 1q duplication can be used as a prognostic factor in the preoperative period.
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spelling pubmed-55583622017-09-14 The effect of first chromosome long arm duplication on survival of endometrial carcinoma Sever, Erman Doğer, Emek Çakıroğlu, Yiğit Sünnetçi, Deniz Çine, Naci Savlı, Hakan Yücesoy, İzzet Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: The aim of this study is to investigate the effect of first chromosome long arm duplication (dup(1q)) in cases with endometrial carcinoma detected with array based comperative genomic hybridization (aCGH) on survival from the cancer. MATERIALS AND METHODS: A total of 53 patients with the diagnosis of endometrial carcinom due to endometrial biopsy and who have been operated for this reason have been allocated in the study. Frozen section biopsy and staging surgery have been performed for all the cases. Samples obtained from the tumoral mass have been investigated for chromosomal aberrations with aCGH method. Kaplan-Meier and Cox-regression analysis have been performed for survival analysis. RESULTS: Among 53 cases with endometrial carcinomas, dup(1q) was diagnosed in 14 (26.4%) of the cases. For the patient group that has been followed-up for 24 months (3-33 months), dup(1q) (p=.01), optimal cytoreduction (p<.001), lymph node positivity (p=.006), tumor stage >1 (p=.006) and presence of high risk tumor were the factors that were associated with survival. Cox-regression analysis has revealed that optimal cytoreduction was the most important prognostic factor (p=.02). CONCLUSION: Presence of 1q duplication can be used as a prognostic factor in the preoperative period. Galenos Publishing 2014-12 2014-12-15 /pmc/articles/PMC5558362/ /pubmed/28913021 http://dx.doi.org/10.4274/tjod.05617 Text en © Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Sever, Erman
Doğer, Emek
Çakıroğlu, Yiğit
Sünnetçi, Deniz
Çine, Naci
Savlı, Hakan
Yücesoy, İzzet
The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title_full The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title_fullStr The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title_full_unstemmed The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title_short The effect of first chromosome long arm duplication on survival of endometrial carcinoma
title_sort effect of first chromosome long arm duplication on survival of endometrial carcinoma
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558362/
https://www.ncbi.nlm.nih.gov/pubmed/28913021
http://dx.doi.org/10.4274/tjod.05617
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