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Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction?
OBJECTIVE: The purpose of the present study was to assess the effect of D-dimer and fibrinogen levels in maternal serum as a marker for detection of intrauterine growth restriction (IUGR). MATERIALS AND METHODS: Two hundred-thirty four pregnant women who get pregnancy follow-up and delivery in the t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558367/ https://www.ncbi.nlm.nih.gov/pubmed/28913026 http://dx.doi.org/10.4274/tjod.39260 |
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author | Tetik, Kerem Seçkin, Kerem Doğa Karslı, Fatih Mehmet Sarıaslan, Seval Çakmak, Bülent Danışman, Nuri |
author_facet | Tetik, Kerem Seçkin, Kerem Doğa Karslı, Fatih Mehmet Sarıaslan, Seval Çakmak, Bülent Danışman, Nuri |
author_sort | Tetik, Kerem |
collection | PubMed |
description | OBJECTIVE: The purpose of the present study was to assess the effect of D-dimer and fibrinogen levels in maternal serum as a marker for detection of intrauterine growth restriction (IUGR). MATERIALS AND METHODS: Two hundred-thirty four pregnant women who get pregnancy follow-up and delivery in the tertiary hospital between January 2011 and December 2011 were admitted to the study. Pregnant women were divided into two groups; group-1: 117 pregnants complicated with IUGR and group-2: 117 healthy pregnants without IUGR as control. Serum D-dimer and fibrinogen levels of all pregnant women were measured in the third trimester. The levels of D-dimer and fibrinogen were compared between two groups. RESULTS: There is no significant difference between the groups for age, body mass index before pregnancy, smoking and gestational weeks (p>0.05). Gravidity, parity, number of children and maternal serum fibrinogen level were detected significantly different between the groups (p<0.001). D-dimer level was not significantly different between the groups (p=0.183), but fibrinogen level in group-1 was found higher than group-2. CONCLUSION: Serum fibrinogen level was found higher in pregnant women complicated with IUGR but D-dimer level was not different between the groups. Although serum D-dimer should not be used as a marker for detection of IUGR, serum fibrinogen may be used. |
format | Online Article Text |
id | pubmed-5558367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-55583672017-09-14 Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? Tetik, Kerem Seçkin, Kerem Doğa Karslı, Fatih Mehmet Sarıaslan, Seval Çakmak, Bülent Danışman, Nuri Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: The purpose of the present study was to assess the effect of D-dimer and fibrinogen levels in maternal serum as a marker for detection of intrauterine growth restriction (IUGR). MATERIALS AND METHODS: Two hundred-thirty four pregnant women who get pregnancy follow-up and delivery in the tertiary hospital between January 2011 and December 2011 were admitted to the study. Pregnant women were divided into two groups; group-1: 117 pregnants complicated with IUGR and group-2: 117 healthy pregnants without IUGR as control. Serum D-dimer and fibrinogen levels of all pregnant women were measured in the third trimester. The levels of D-dimer and fibrinogen were compared between two groups. RESULTS: There is no significant difference between the groups for age, body mass index before pregnancy, smoking and gestational weeks (p>0.05). Gravidity, parity, number of children and maternal serum fibrinogen level were detected significantly different between the groups (p<0.001). D-dimer level was not significantly different between the groups (p=0.183), but fibrinogen level in group-1 was found higher than group-2. CONCLUSION: Serum fibrinogen level was found higher in pregnant women complicated with IUGR but D-dimer level was not different between the groups. Although serum D-dimer should not be used as a marker for detection of IUGR, serum fibrinogen may be used. Galenos Publishing 2014-12 2014-12-15 /pmc/articles/PMC5558367/ /pubmed/28913026 http://dx.doi.org/10.4274/tjod.39260 Text en © Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Tetik, Kerem Seçkin, Kerem Doğa Karslı, Fatih Mehmet Sarıaslan, Seval Çakmak, Bülent Danışman, Nuri Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title | Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title_full | Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title_fullStr | Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title_full_unstemmed | Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title_short | Can we use as a marker the maternal serum levels of D-dimer and fibrinogen to predict intra uterin growth restriction? |
title_sort | can we use as a marker the maternal serum levels of d-dimer and fibrinogen to predict intra uterin growth restriction? |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558367/ https://www.ncbi.nlm.nih.gov/pubmed/28913026 http://dx.doi.org/10.4274/tjod.39260 |
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