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Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance

OBJECTIVE: Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS. MATER...

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Autores principales: Erkan, Gönül, Tayyar, Ahter Tanay, Açmaz, Gökhan, Müderris, İptisam İpek, Başkol, Gülden, Bayram, Fahri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558419/
https://www.ncbi.nlm.nih.gov/pubmed/28913143
http://dx.doi.org/10.4274/tjod.61224
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author Erkan, Gönül
Tayyar, Ahter Tanay
Açmaz, Gökhan
Müderris, İptisam İpek
Başkol, Gülden
Bayram, Fahri
author_facet Erkan, Gönül
Tayyar, Ahter Tanay
Açmaz, Gökhan
Müderris, İptisam İpek
Başkol, Gülden
Bayram, Fahri
author_sort Erkan, Gönül
collection PubMed
description OBJECTIVE: Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS. MATERIALS AND METHODS: A total of 60 women were divided into two groups. The first group constituted 44 patients with PCOS and the control group comprised 16 healthy women. Osteocalcin, adiponectin, TNF-α levels, body mass index (BMI), and IR in the fasting state were assessed and correlations of these parameters were evaluated. RESULTS: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group. A moderate positive correlation between BMI and HOMA-IR, a moderate negative correlation between TNF-α and osteocalcin, and a mild negative correlation between adiponectin and BMI were detected in PCOS. CONCLUSION: Osteocalcin may have impact on adiponectin, TNF-α, and IR levels in PCOS. Different osteocalcin levels in patients with PCOS may be responsible for explaining PCOS heterogeneity.
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spelling pubmed-55584192017-09-14 Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance Erkan, Gönül Tayyar, Ahter Tanay Açmaz, Gökhan Müderris, İptisam İpek Başkol, Gülden Bayram, Fahri Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS. MATERIALS AND METHODS: A total of 60 women were divided into two groups. The first group constituted 44 patients with PCOS and the control group comprised 16 healthy women. Osteocalcin, adiponectin, TNF-α levels, body mass index (BMI), and IR in the fasting state were assessed and correlations of these parameters were evaluated. RESULTS: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group. A moderate positive correlation between BMI and HOMA-IR, a moderate negative correlation between TNF-α and osteocalcin, and a mild negative correlation between adiponectin and BMI were detected in PCOS. CONCLUSION: Osteocalcin may have impact on adiponectin, TNF-α, and IR levels in PCOS. Different osteocalcin levels in patients with PCOS may be responsible for explaining PCOS heterogeneity. Galenos Publishing 2017-06 2017-06-15 /pmc/articles/PMC5558419/ /pubmed/28913143 http://dx.doi.org/10.4274/tjod.61224 Text en ©Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Erkan, Gönül
Tayyar, Ahter Tanay
Açmaz, Gökhan
Müderris, İptisam İpek
Başkol, Gülden
Bayram, Fahri
Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title_full Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title_fullStr Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title_full_unstemmed Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title_short Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
title_sort role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558419/
https://www.ncbi.nlm.nih.gov/pubmed/28913143
http://dx.doi.org/10.4274/tjod.61224
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