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Impact of glucocorticoid on neurogenesis

Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of...

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Detalles Bibliográficos
Autores principales: Odaka, Haruki, Adachi, Naoki, Numakawa, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558474/
https://www.ncbi.nlm.nih.gov/pubmed/28852377
http://dx.doi.org/10.4103/1673-5374.211174
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author Odaka, Haruki
Adachi, Naoki
Numakawa, Tadahiro
author_facet Odaka, Haruki
Adachi, Naoki
Numakawa, Tadahiro
author_sort Odaka, Haruki
collection PubMed
description Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors. Moreover, proliferation/differentiation of the neural stem/progenitor cells (NSPCs) is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt, hedgehog, and Wnt. Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms; this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases.
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spelling pubmed-55584742017-08-29 Impact of glucocorticoid on neurogenesis Odaka, Haruki Adachi, Naoki Numakawa, Tadahiro Neural Regen Res Invited Review Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors. Moreover, proliferation/differentiation of the neural stem/progenitor cells (NSPCs) is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt, hedgehog, and Wnt. Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms; this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases. Medknow Publications & Media Pvt Ltd 2017-07 /pmc/articles/PMC5558474/ /pubmed/28852377 http://dx.doi.org/10.4103/1673-5374.211174 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Odaka, Haruki
Adachi, Naoki
Numakawa, Tadahiro
Impact of glucocorticoid on neurogenesis
title Impact of glucocorticoid on neurogenesis
title_full Impact of glucocorticoid on neurogenesis
title_fullStr Impact of glucocorticoid on neurogenesis
title_full_unstemmed Impact of glucocorticoid on neurogenesis
title_short Impact of glucocorticoid on neurogenesis
title_sort impact of glucocorticoid on neurogenesis
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558474/
https://www.ncbi.nlm.nih.gov/pubmed/28852377
http://dx.doi.org/10.4103/1673-5374.211174
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