Spinal cord injury drives chronic brain changes

Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognit...

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Detalles Bibliográficos
Autores principales: Jure, Ignacio, Labombarda, Florencia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558477/
https://www.ncbi.nlm.nih.gov/pubmed/28852380
http://dx.doi.org/10.4103/1673-5374.211177
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author Jure, Ignacio
Labombarda, Florencia
author_facet Jure, Ignacio
Labombarda, Florencia
author_sort Jure, Ignacio
collection PubMed
description Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
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spelling pubmed-55584772017-08-29 Spinal cord injury drives chronic brain changes Jure, Ignacio Labombarda, Florencia Neural Regen Res Invited Review Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma. Medknow Publications & Media Pvt Ltd 2017-07 /pmc/articles/PMC5558477/ /pubmed/28852380 http://dx.doi.org/10.4103/1673-5374.211177 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Jure, Ignacio
Labombarda, Florencia
Spinal cord injury drives chronic brain changes
title Spinal cord injury drives chronic brain changes
title_full Spinal cord injury drives chronic brain changes
title_fullStr Spinal cord injury drives chronic brain changes
title_full_unstemmed Spinal cord injury drives chronic brain changes
title_short Spinal cord injury drives chronic brain changes
title_sort spinal cord injury drives chronic brain changes
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558477/
https://www.ncbi.nlm.nih.gov/pubmed/28852380
http://dx.doi.org/10.4103/1673-5374.211177
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