Cargando…

Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration

BACKGROUND: Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis. HYPOTHESIS: We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening too...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatzinikolaou-Kotsakou, Eleni, Kartasis, Zafirios, Tziakas, Dimitrios, Stakos, Dimitrios, Hotidis, Athanasios, Chalikias, Georgios, Bourikas, Georgios, Hatseras, Dimitrios I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555849/
https://www.ncbi.nlm.nih.gov/pubmed/15748296
http://dx.doi.org/10.1186/1477-9560-3-2
_version_ 1782122562417852416
author Hatzinikolaou-Kotsakou, Eleni
Kartasis, Zafirios
Tziakas, Dimitrios
Stakos, Dimitrios
Hotidis, Athanasios
Chalikias, Georgios
Bourikas, Georgios
Hatseras, Dimitrios I
author_facet Hatzinikolaou-Kotsakou, Eleni
Kartasis, Zafirios
Tziakas, Dimitrios
Stakos, Dimitrios
Hotidis, Athanasios
Chalikias, Georgios
Bourikas, Georgios
Hatseras, Dimitrios I
author_sort Hatzinikolaou-Kotsakou, Eleni
collection PubMed
description BACKGROUND: Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis. HYPOTHESIS: We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening tool of this clotting status, and iii) the duration of arrhythmia influences the haemostasis measured by plasma D-Dimer levels. METHODS: Forty-two patients with atrial fibrillation undergoing cardioversion were divided into two groups: in Group A (n = 24,14 male, 56 ± 11 years) the duration of atrial fibrillation was 72 hours or more (142.7 ± 103.8 hours), in Group B (n = 18, 10 male, 61 ± 13 years) the duration of atrial fibrillation was less than 72 hours (25 ± 16 hours). Plasma fibrin D-dimer levels were measured by enzyme immunoassay before, and 36 hours after, cardioversion. The change of plasma D-dimer levels 36 hours after cardioversion was calculated as delta-D-dimer. RESULTS: There were no significant differences in demographic, clinical, and echocardiographic data, and the success of cardioversion between the two groups. Compared to the control, the baseline D-dimer levels were significantly higher in both groups. The delta D-dimer levels were significantly higher in Group A than in Group B (p < 0.005). Furthermore, plasma D-dimer levels 36 hours after cardioversion (r = 0.52, p = 0.0016) and delta-D-dimer levels (r = 0.73, p < 0.0001) showed significant correlations with the duration of atrial fibrillation. CONCLUSION: The longer duration of the atrial fibrillation episode could lead to a more prominent cardiovascular hyperclotting state after cardioversion, and the mean changes of plasma D-Dimer levels could be used as an useful clinical marker of the clotting state after atrial systole return.
format Text
id pubmed-555849
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-5558492005-04-02 Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration Hatzinikolaou-Kotsakou, Eleni Kartasis, Zafirios Tziakas, Dimitrios Stakos, Dimitrios Hotidis, Athanasios Chalikias, Georgios Bourikas, Georgios Hatseras, Dimitrios I Thromb J Original Clinical Investigation BACKGROUND: Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis. HYPOTHESIS: We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening tool of this clotting status, and iii) the duration of arrhythmia influences the haemostasis measured by plasma D-Dimer levels. METHODS: Forty-two patients with atrial fibrillation undergoing cardioversion were divided into two groups: in Group A (n = 24,14 male, 56 ± 11 years) the duration of atrial fibrillation was 72 hours or more (142.7 ± 103.8 hours), in Group B (n = 18, 10 male, 61 ± 13 years) the duration of atrial fibrillation was less than 72 hours (25 ± 16 hours). Plasma fibrin D-dimer levels were measured by enzyme immunoassay before, and 36 hours after, cardioversion. The change of plasma D-dimer levels 36 hours after cardioversion was calculated as delta-D-dimer. RESULTS: There were no significant differences in demographic, clinical, and echocardiographic data, and the success of cardioversion between the two groups. Compared to the control, the baseline D-dimer levels were significantly higher in both groups. The delta D-dimer levels were significantly higher in Group A than in Group B (p < 0.005). Furthermore, plasma D-dimer levels 36 hours after cardioversion (r = 0.52, p = 0.0016) and delta-D-dimer levels (r = 0.73, p < 0.0001) showed significant correlations with the duration of atrial fibrillation. CONCLUSION: The longer duration of the atrial fibrillation episode could lead to a more prominent cardiovascular hyperclotting state after cardioversion, and the mean changes of plasma D-Dimer levels could be used as an useful clinical marker of the clotting state after atrial systole return. BioMed Central 2005-03-06 /pmc/articles/PMC555849/ /pubmed/15748296 http://dx.doi.org/10.1186/1477-9560-3-2 Text en Copyright © 2005 Hatzinikolaou-Kotsakou et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Clinical Investigation
Hatzinikolaou-Kotsakou, Eleni
Kartasis, Zafirios
Tziakas, Dimitrios
Stakos, Dimitrios
Hotidis, Athanasios
Chalikias, Georgios
Bourikas, Georgios
Hatseras, Dimitrios I
Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title_full Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title_fullStr Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title_full_unstemmed Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title_short Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
title_sort clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration
topic Original Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555849/
https://www.ncbi.nlm.nih.gov/pubmed/15748296
http://dx.doi.org/10.1186/1477-9560-3-2
work_keys_str_mv AT hatzinikolaoukotsakoueleni clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT kartasiszafirios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT tziakasdimitrios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT stakosdimitrios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT hotidisathanasios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT chalikiasgeorgios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT bourikasgeorgios clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration
AT hatserasdimitriosi clottingstateaftercardioversionofatrialfibrillationahaemostasisindexcoulddetecttherelationshipwiththearrhythmiaduration