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A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity

A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LD...

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Autores principales: Li, Xingshu, Zheng, Bi-Yuan, Ke, Mei-Rong, Zhang, Yongfan, Huang, Jian-Dong, Yoon, Juyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558566/
https://www.ncbi.nlm.nih.gov/pubmed/28819460
http://dx.doi.org/10.7150/thno.18861
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author Li, Xingshu
Zheng, Bi-Yuan
Ke, Mei-Rong
Zhang, Yongfan
Huang, Jian-Dong
Yoon, Juyoung
author_facet Li, Xingshu
Zheng, Bi-Yuan
Ke, Mei-Rong
Zhang, Yongfan
Huang, Jian-Dong
Yoon, Juyoung
author_sort Li, Xingshu
collection PubMed
description A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS(8), which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS(8 )is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS(8)) and cationic hydroxide layers of layered double hydroxide (LDH). The in vitro photodynamic activities of LDH-ZnPcS(8 )in cancer cells are dramatically enhanced relative to those of ZnPcS(8) alone. The results of in vivo fluorescence imaging demonstrate that the nanohybrid is activated in tumor tissues, where it displays an excellent PDT effect resulting in 95.3% tumor growth inhibition. Furthermore, the minimal skin phototoxicity of LDH-ZnPcS(8) highlights its high potential as a novel photosensitizer for activatable PDT.
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spelling pubmed-55585662017-08-17 A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity Li, Xingshu Zheng, Bi-Yuan Ke, Mei-Rong Zhang, Yongfan Huang, Jian-Dong Yoon, Juyoung Theranostics Research Paper A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS(8), which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS(8 )is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS(8)) and cationic hydroxide layers of layered double hydroxide (LDH). The in vitro photodynamic activities of LDH-ZnPcS(8 )in cancer cells are dramatically enhanced relative to those of ZnPcS(8) alone. The results of in vivo fluorescence imaging demonstrate that the nanohybrid is activated in tumor tissues, where it displays an excellent PDT effect resulting in 95.3% tumor growth inhibition. Furthermore, the minimal skin phototoxicity of LDH-ZnPcS(8) highlights its high potential as a novel photosensitizer for activatable PDT. Ivyspring International Publisher 2017-07-07 /pmc/articles/PMC5558566/ /pubmed/28819460 http://dx.doi.org/10.7150/thno.18861 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Li, Xingshu
Zheng, Bi-Yuan
Ke, Mei-Rong
Zhang, Yongfan
Huang, Jian-Dong
Yoon, Juyoung
A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title_full A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title_fullStr A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title_full_unstemmed A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title_short A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
title_sort tumor-ph-responsive supramolecular photosensitizer for activatable photodynamic therapy with minimal in vivo skin phototoxicity
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558566/
https://www.ncbi.nlm.nih.gov/pubmed/28819460
http://dx.doi.org/10.7150/thno.18861
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