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A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity
A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LD...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558566/ https://www.ncbi.nlm.nih.gov/pubmed/28819460 http://dx.doi.org/10.7150/thno.18861 |
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author | Li, Xingshu Zheng, Bi-Yuan Ke, Mei-Rong Zhang, Yongfan Huang, Jian-Dong Yoon, Juyoung |
author_facet | Li, Xingshu Zheng, Bi-Yuan Ke, Mei-Rong Zhang, Yongfan Huang, Jian-Dong Yoon, Juyoung |
author_sort | Li, Xingshu |
collection | PubMed |
description | A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS(8), which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS(8 )is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS(8)) and cationic hydroxide layers of layered double hydroxide (LDH). The in vitro photodynamic activities of LDH-ZnPcS(8 )in cancer cells are dramatically enhanced relative to those of ZnPcS(8) alone. The results of in vivo fluorescence imaging demonstrate that the nanohybrid is activated in tumor tissues, where it displays an excellent PDT effect resulting in 95.3% tumor growth inhibition. Furthermore, the minimal skin phototoxicity of LDH-ZnPcS(8) highlights its high potential as a novel photosensitizer for activatable PDT. |
format | Online Article Text |
id | pubmed-5558566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-55585662017-08-17 A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity Li, Xingshu Zheng, Bi-Yuan Ke, Mei-Rong Zhang, Yongfan Huang, Jian-Dong Yoon, Juyoung Theranostics Research Paper A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS(8), which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS(8 )is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS(8)) and cationic hydroxide layers of layered double hydroxide (LDH). The in vitro photodynamic activities of LDH-ZnPcS(8 )in cancer cells are dramatically enhanced relative to those of ZnPcS(8) alone. The results of in vivo fluorescence imaging demonstrate that the nanohybrid is activated in tumor tissues, where it displays an excellent PDT effect resulting in 95.3% tumor growth inhibition. Furthermore, the minimal skin phototoxicity of LDH-ZnPcS(8) highlights its high potential as a novel photosensitizer for activatable PDT. Ivyspring International Publisher 2017-07-07 /pmc/articles/PMC5558566/ /pubmed/28819460 http://dx.doi.org/10.7150/thno.18861 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Li, Xingshu Zheng, Bi-Yuan Ke, Mei-Rong Zhang, Yongfan Huang, Jian-Dong Yoon, Juyoung A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title | A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title_full | A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title_fullStr | A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title_full_unstemmed | A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title_short | A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity |
title_sort | tumor-ph-responsive supramolecular photosensitizer for activatable photodynamic therapy with minimal in vivo skin phototoxicity |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558566/ https://www.ncbi.nlm.nih.gov/pubmed/28819460 http://dx.doi.org/10.7150/thno.18861 |
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