High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease

BACKGROUND & AIMS: The high replication and mutation rate of hepatitis C virus (HCV) results in a heterogeneous population of viral sequences in vivo. HCV replicates in the liver and infected hepatocytes occur as foci surrounded by uninfected cells that may promote compartmentalization of viral...

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Detalles Bibliográficos
Autores principales: Hedegaard, Ditte L., Tully, Damien C., Rowe, Ian A., Reynolds, Gary M., Bean, David J., Hu, Ke, Davis, Christopher, Wilhelm, Annika, Ogilvie, Colin B., Power, Karen A., Tarr, Alexander W., Kelly, Deirdre, Allen, Todd M., Balfe, Peter, McKeating, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558612/
https://www.ncbi.nlm.nih.gov/pubmed/27531641
http://dx.doi.org/10.1016/j.jhep.2016.07.048

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