Cargando…

Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies

BACKGROUND: There has been increasing interest in the detection of tumour exosomes in blood for cancer diagnostics. Most studies have focussed on miRNA and protein signatures that are surrogate markers for specific tumour types. Because tumour cells and tumour-derived exosomes display phosphatidylse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Raghava, Huang, Xianming, Brekken, Rolf A, Schroit, Alan J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558679/ https://www.ncbi.nlm.nih.gov/pubmed/28641308 http://dx.doi.org/10.1038/bjc.2017.183

Ejemplares similares

Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study
por: Lea, Jayanthi, et al.
Publicado: (2017)

Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer
por: Belzile, Olivier, et al.
Publicado: (2018)

Antibody-mediated phosphatidylserine blockade significantly enhances the efficacy of downstream immune checkpoint inhibition in K1735 mouse melanoma
por: Huang, Xianming, et al.
Publicado: (2014)

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates
por: Ayaru, L, et al.
Publicado: (2008)

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology
por: Keane, Margaret G, et al.
Publicado: (2017)

Early diagnosis of bladder cancer through the detection of urinary tyrosine-phosphorylated proteins
por: Khadjavi, A, et al.
Publicado: (2015)

Testing breast cancer serum biomarkers for early detection and prognosis in pre-diagnosis samples
por: Kazarian, Anna, et al.
Publicado: (2017)

Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control
por: Seidel, A, et al.
Publicado: (2006)

A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer
por: Molloy, T J, et al.
Publicado: (2011)

Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis
por: Kirschner, Michaela B, et al.
Publicado: (2015)

CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells
por: Miki, Yuichiro, et al.
Publicado: (2018)

A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma
por: Yie, Shang-mian, et al.
Publicado: (2016)

Molecular detection of persistent postoperative circulating tumour cells in stages II and III colon cancer patients via multiple blood sampling: prognostic significance of detection for early relapse
por: Lu, C-Y, et al.
Publicado: (2011)

Circulating tumour cells as a biomarker for diagnosis and staging in pancreatic cancer
por: Ankeny, J S, et al.
Publicado: (2016)

Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations
por: Pinato, D J, et al.
Publicado: (2013)

Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies
por: Roy, R, et al.
Publicado: (2014)

Assessment of DNA methylation status in early stages of breast cancer development
por: van Hoesel, A Q, et al.
Publicado: (2013)

Utility of risk-weighted surgical–pathological factors in early-stage cervical cancer
por: Matsuo, K, et al.
Publicado: (2013)

Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive
por: O'Toole, A, et al.
Publicado: (2014)

Favourable prognostic role of histological regression in stage III positive sentinel lymph node melanoma patients
por: Zugna, D, et al.
Publicado: (2018)

Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer
por: Boldrini, L, et al.
Publicado: (2005)

Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
por: Snoeren, N, et al.
Publicado: (2013)

Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer
por: Benard, A, et al.
Publicado: (2013)

Serum microRNA panel as biomarkers for early diagnosis of colorectal adenocarcinoma
por: Zheng, G, et al.
Publicado: (2014)

Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
por: Taylor, D D, et al.
Publicado: (2005)

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer
por: Huang, Y-F, et al.
Publicado: (2008)

High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancer
por: Böckelman, C, et al.
Publicado: (2011)

Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer
por: Cihoric, N, et al.
Publicado: (2014)

Identification of biomarkers for lymph node metastasis in early-stage cervical cancer by tissue-based proteomics
por: Wang, W, et al.
Publicado: (2014)

Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups
por: Sundquist, Elias, et al.
Publicado: (2017)

Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments
por: Dudderidge, T J, et al.
Publicado: (2010)

P4H9-detected molecule expression on spindle-shaped fibroblasts indicates malignant phenotype of colorectal cancer
por: Yokoyama, Shozo, et al.
Publicado: (2015)

Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
por: Matsumura, T, et al.
Publicado: (2015)

Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
por: Moniaux, N, et al.
Publicado: (2008)

Malignant melanoma and bone resorption
por: Lau, Y S, et al.
Publicado: (2006)

Dynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer
por: Yuan, Zixu, et al.
Publicado: (2017)

Role of fine-needle aspiration cytology and core biopsy in the preoperative diagnosis of screen-detected breast carcinoma
por: Lieske, B, et al.
Publicado: (2006)

Accurate and rapid novel genetic diagnosis for detection of sentinel lymph node metastasis in breast cancer patients
por: Iinuma, H, et al.
Publicado: (2012)

Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine
por: Saeb-Parsy, K, et al.
Publicado: (2012)

The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma
por: Pinato, D J, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_udnrjvc7q2kj19ncmr3drtn05o