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Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening

BACKGROUND: To reduce colorectal cancer (CRC) mortality through population-based screening programmes using faecal tests, it is important that individuals continue to participate in the repeated rounds of screening. We aimed to identify lifestyle predictors for discontinuation of faecal immunochemic...

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Autores principales: Knudsen, Markus Dines, Berstad, Paula, Hjartåker, Anette, Gulichsen, Elisabeth Haagensen, Hoff, Geir, de Lange, Thomas, Bernklev, Tomm, Botteri, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558680/
https://www.ncbi.nlm.nih.gov/pubmed/28704841
http://dx.doi.org/10.1038/bjc.2017.189
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author Knudsen, Markus Dines
Berstad, Paula
Hjartåker, Anette
Gulichsen, Elisabeth Haagensen
Hoff, Geir
de Lange, Thomas
Bernklev, Tomm
Botteri, Edoardo
author_facet Knudsen, Markus Dines
Berstad, Paula
Hjartåker, Anette
Gulichsen, Elisabeth Haagensen
Hoff, Geir
de Lange, Thomas
Bernklev, Tomm
Botteri, Edoardo
author_sort Knudsen, Markus Dines
collection PubMed
description BACKGROUND: To reduce colorectal cancer (CRC) mortality through population-based screening programmes using faecal tests, it is important that individuals continue to participate in the repeated rounds of screening. We aimed to identify lifestyle predictors for discontinuation of faecal immunochemical test (FIT) screening after the first round, as well as lifestyle predictors for colorectal neoplasia detected in the second-round FIT screening. METHODS: In this longitudinal study, we invited 6959 individuals aged 50–74 years from south-east Norway for a first round of FIT screening and to complete a self-reported lifestyle questionnaire on demographic factors, body mass index (BMI, kg m(−2)), smoking habits, physical activity, consumption of alcohol and dietary items. Two years later, we estimated the associations between these factors, non-participation and screening results in the second round of FIT screening using adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Of the 3114 responders to the questionnaire who completed the first-round FIT and who were invited to participate in second-round FIT screening, 540 (17%) did not participate. The OR and (95% CI) for discontinuation of FIT screening after the first round was 1.61 (1.24–2.10) for current smoking compared with non-smoking; 2.01 (1.25–3.24) for BMI⩾35 kg m(−2) compared with BMI 16.9–24.9 kg m(−2) and 0.70 (0.52–0.94) for physical activity in the third quartile vs the first. Among participants, smoking, high BMI and high alcohol consumption were associated with an increased odds of detecting colorectal neoplasia (n=107). CONCLUSIONS: These results may indicate that Norwegian FIT screening participants who discontinue after the first round have lifestyle behaviours associated with increased risk of CRC.
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spelling pubmed-55586802018-08-08 Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening Knudsen, Markus Dines Berstad, Paula Hjartåker, Anette Gulichsen, Elisabeth Haagensen Hoff, Geir de Lange, Thomas Bernklev, Tomm Botteri, Edoardo Br J Cancer Clinical Study BACKGROUND: To reduce colorectal cancer (CRC) mortality through population-based screening programmes using faecal tests, it is important that individuals continue to participate in the repeated rounds of screening. We aimed to identify lifestyle predictors for discontinuation of faecal immunochemical test (FIT) screening after the first round, as well as lifestyle predictors for colorectal neoplasia detected in the second-round FIT screening. METHODS: In this longitudinal study, we invited 6959 individuals aged 50–74 years from south-east Norway for a first round of FIT screening and to complete a self-reported lifestyle questionnaire on demographic factors, body mass index (BMI, kg m(−2)), smoking habits, physical activity, consumption of alcohol and dietary items. Two years later, we estimated the associations between these factors, non-participation and screening results in the second round of FIT screening using adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Of the 3114 responders to the questionnaire who completed the first-round FIT and who were invited to participate in second-round FIT screening, 540 (17%) did not participate. The OR and (95% CI) for discontinuation of FIT screening after the first round was 1.61 (1.24–2.10) for current smoking compared with non-smoking; 2.01 (1.25–3.24) for BMI⩾35 kg m(−2) compared with BMI 16.9–24.9 kg m(−2) and 0.70 (0.52–0.94) for physical activity in the third quartile vs the first. Among participants, smoking, high BMI and high alcohol consumption were associated with an increased odds of detecting colorectal neoplasia (n=107). CONCLUSIONS: These results may indicate that Norwegian FIT screening participants who discontinue after the first round have lifestyle behaviours associated with increased risk of CRC. Nature Publishing Group 2017-08-08 2017-07-13 /pmc/articles/PMC5558680/ /pubmed/28704841 http://dx.doi.org/10.1038/bjc.2017.189 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Clinical Study
Knudsen, Markus Dines
Berstad, Paula
Hjartåker, Anette
Gulichsen, Elisabeth Haagensen
Hoff, Geir
de Lange, Thomas
Bernklev, Tomm
Botteri, Edoardo
Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title_full Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title_fullStr Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title_full_unstemmed Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title_short Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
title_sort lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558680/
https://www.ncbi.nlm.nih.gov/pubmed/28704841
http://dx.doi.org/10.1038/bjc.2017.189
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