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Absence of CX3CR1 impairs the internalization of Tau by microglia

BACKGROUND: Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. METHODS: We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, a...

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Detalles Bibliográficos
Autores principales:	Bolós, Marta, Llorens-Martín, María, Perea, Juan Ramón, Jurado-Arjona, Jerónimo, Rábano, Alberto, Hernández, Félix, Avila, Jesús
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558740/ https://www.ncbi.nlm.nih.gov/pubmed/28810892 http://dx.doi.org/10.1186/s13024-017-0200-1

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