The power of the few

Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components i...

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Detalles Bibliográficos
Autores principales: Chen, Ran, Pan, Yuan, Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558920/
https://www.ncbi.nlm.nih.gov/pubmed/28765159
http://dx.doi.org/10.1101/gad.303453.117
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author Chen, Ran
Pan, Yuan
Gutmann, David H.
author_facet Chen, Ran
Pan, Yuan
Gutmann, David H.
author_sort Chen, Ran
collection PubMed
description Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components is vital to the design of effective therapies against these cancers. In this issue of Genes & Development, Zanca and colleagues (pp. 1212–1227) demonstrate that one subpopulation of glioblastoma cells expressing a mutant epidermal growth factor receptor (EGFRvIII) is responsible for the survival of non-EGFRvIII-expressing tumor cells as well as for evading molecularly targeted therapy.
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spelling pubmed-55589202017-12-15 The power of the few Chen, Ran Pan, Yuan Gutmann, David H. Genes Dev Outlook Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components is vital to the design of effective therapies against these cancers. In this issue of Genes & Development, Zanca and colleagues (pp. 1212–1227) demonstrate that one subpopulation of glioblastoma cells expressing a mutant epidermal growth factor receptor (EGFRvIII) is responsible for the survival of non-EGFRvIII-expressing tumor cells as well as for evading molecularly targeted therapy. Cold Spring Harbor Laboratory Press 2017-06-15 /pmc/articles/PMC5558920/ /pubmed/28765159 http://dx.doi.org/10.1101/gad.303453.117 Text en © 2017 Chen et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Chen, Ran
Pan, Yuan
Gutmann, David H.
The power of the few
title The power of the few
title_full The power of the few
title_fullStr The power of the few
title_full_unstemmed The power of the few
title_short The power of the few
title_sort power of the few
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558920/
https://www.ncbi.nlm.nih.gov/pubmed/28765159
http://dx.doi.org/10.1101/gad.303453.117
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