Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity

In glioblastoma (GBM), heterogeneous expression of amplified and mutated epidermal growth factor receptor (EGFR) presents a substantial challenge for the effective use of EGFR-directed therapeutics. Here we demonstrate that heterogeneous expression of the wild-type receptor and its constitutively ac...

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Detalles Bibliográficos
Autores principales: Zanca, Ciro, Villa, Genaro R., Benitez, Jorge A., Thorne, Amy Haseley, Koga, Tomoyuki, D'Antonio, Matteo, Ikegami, Shiro, Ma, Jianhui, Boyer, Antonia D., Banisadr, Afsheen, Jameson, Nathan M., Parisian, Alison D., Eliseeva, Olesja V., Barnabe, Gabriela F., Liu, Feng, Wu, Sihan, Yang, Huijun, Wykosky, Jill, Frazer, Kelly A., Verkhusha, Vladislav V., Isaguliants, Maria G., Weiss, William A., Gahman, Timothy C., Shiau, Andrew K., Chen, Clark C., Mischel, Paul S., Cavenee, Webster K., Furnari, Frank B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558924/
https://www.ncbi.nlm.nih.gov/pubmed/28724615
http://dx.doi.org/10.1101/gad.300079.117

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