An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression

Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome targeting) functions to facilitate turnover of some of these lncRNAs. Here we show that knockdown of one NEXT subunit, Mtr4, but neither...

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Detalles Bibliográficos
Autores principales: Ogami, Koichi, Richard, Patricia, Chen, Yaqiong, Hoque, Mainul, Li, Wencheng, Moresco, James J., Yates, John R., Tian, Bin, Manley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558927/
https://www.ncbi.nlm.nih.gov/pubmed/28733371
http://dx.doi.org/10.1101/gad.302604.117

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