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Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG

Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermi...

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Autores principales: Kienast, Roland, Handler, Michael, Stöger, Markus, Baumgarten, Daniel, Hanser, Friedrich, Baumgartner, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558962/
https://www.ncbi.nlm.nih.gov/pubmed/28813535
http://dx.doi.org/10.1371/journal.pone.0182979
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author Kienast, Roland
Handler, Michael
Stöger, Markus
Baumgarten, Daniel
Hanser, Friedrich
Baumgartner, Christian
author_facet Kienast, Roland
Handler, Michael
Stöger, Markus
Baumgarten, Daniel
Hanser, Friedrich
Baumgartner, Christian
author_sort Kienast, Roland
collection PubMed
description Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. In this work, we propose a model that describes the cooling-induced electrophysiological alterations in ventricular tissue in a temperature range from 27°C to 37°C. To model the electrophysiological conditions in a 3D left ventricular tissue block it was essential to consider the following anatomical and physiological parameters in the model: the different cell types (endocardial, M, epicardial), the heterogeneous conductivities in longitudinal, transversal and transmural direction depending on the prevailing temperature, the distinct fiber orientations and the transmural repolarization sequences. Cooling-induced alterations on the morphology of the action potential (AP) of single myocardial cells thereby are described by an extension of the selected Bueno-Orovio model for human ventricular tissue using Q10 temperature coefficients. To evaluate alterations on tissue level, the corresponding pseudo electrocardiogram (pECG) was calculated. Simulations show that cooling-induced AP and pECG-related parameters, i.e. AP duration, morphology of the notch of epicardial AP, maximum AP upstroke velocity, AP rise time, QT interval, QRS duration and J wave formation are in good accordance with literature and our experimental data. The proposed model enables us to further enhance our knowledge of cooling-induced electrophysiological alterations from cellular to tissue level in the heart and may help to better understand electrophysiological mechanisms, e.g. in arrhythmias, during hypothermia.
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spelling pubmed-55589622017-08-25 Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG Kienast, Roland Handler, Michael Stöger, Markus Baumgarten, Daniel Hanser, Friedrich Baumgartner, Christian PLoS One Research Article Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. In this work, we propose a model that describes the cooling-induced electrophysiological alterations in ventricular tissue in a temperature range from 27°C to 37°C. To model the electrophysiological conditions in a 3D left ventricular tissue block it was essential to consider the following anatomical and physiological parameters in the model: the different cell types (endocardial, M, epicardial), the heterogeneous conductivities in longitudinal, transversal and transmural direction depending on the prevailing temperature, the distinct fiber orientations and the transmural repolarization sequences. Cooling-induced alterations on the morphology of the action potential (AP) of single myocardial cells thereby are described by an extension of the selected Bueno-Orovio model for human ventricular tissue using Q10 temperature coefficients. To evaluate alterations on tissue level, the corresponding pseudo electrocardiogram (pECG) was calculated. Simulations show that cooling-induced AP and pECG-related parameters, i.e. AP duration, morphology of the notch of epicardial AP, maximum AP upstroke velocity, AP rise time, QT interval, QRS duration and J wave formation are in good accordance with literature and our experimental data. The proposed model enables us to further enhance our knowledge of cooling-induced electrophysiological alterations from cellular to tissue level in the heart and may help to better understand electrophysiological mechanisms, e.g. in arrhythmias, during hypothermia. Public Library of Science 2017-08-16 /pmc/articles/PMC5558962/ /pubmed/28813535 http://dx.doi.org/10.1371/journal.pone.0182979 Text en © 2017 Kienast et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kienast, Roland
Handler, Michael
Stöger, Markus
Baumgarten, Daniel
Hanser, Friedrich
Baumgartner, Christian
Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title_full Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title_fullStr Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title_full_unstemmed Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title_short Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG
title_sort modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ecg
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558962/
https://www.ncbi.nlm.nih.gov/pubmed/28813535
http://dx.doi.org/10.1371/journal.pone.0182979
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