Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

BACKGROUND: Chloroquine (CQ) is the main anti-schizontocidal drug used in the treatment of uncomplicated malaria caused by Plasmodium vivax. Chloroquine resistant P. vivax (PvCR) malaria in the Western Pacific region, Asia and in the Americas indicates a need for biomarkers of resistance to improve...

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Detalles Bibliográficos
Autores principales: Uppal, Karan, Salinas, Jorge L., Monteiro, Wuelton M., Val, Fernando, Cordy, Regina J., Liu, Ken, Melo, Gisely C., Siqueira, Andre M., Magalhaes, Belisa, Galinski, Mary R., Lacerda, Marcus V. G., Jones, Dean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559093/
https://www.ncbi.nlm.nih.gov/pubmed/28813452
http://dx.doi.org/10.1371/journal.pone.0182819

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