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Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs) such as WASP, plays an important role in many actin-mediated cellular processes. In yeast, Arp2/3-mediated actin filament assembly drives endocytic membrane invagination and vesicle scission. Here we used ge...

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Detalles Bibliográficos
Autores principales:	Sun, Yidi, Leong, Nicole T, Jiang, Tommy, Tangara, Astou, Darzacq, Xavier, Drubin, David G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559269/ https://www.ncbi.nlm.nih.gov/pubmed/28813247 http://dx.doi.org/10.7554/eLife.29140

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