Cargando…
O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres
BACKGROUND: PET using O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological differences between two centres for tumour characterization with (18)F-FET...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559408/ https://www.ncbi.nlm.nih.gov/pubmed/28815478 http://dx.doi.org/10.1186/s13550-017-0316-x |
_version_ | 1783257508602707968 |
---|---|
author | Filss, Christian P. Albert, Nathalie L. Böning, Guido Kops, Elena Rota Suchorska, Bogdana Stoffels, Gabriele Galldiks, Norbert Shah, Nadim J. Mottaghy, Felix M. Bartenstein, Peter Tonn, Jörg C. Langen, Karl-Josef |
author_facet | Filss, Christian P. Albert, Nathalie L. Böning, Guido Kops, Elena Rota Suchorska, Bogdana Stoffels, Gabriele Galldiks, Norbert Shah, Nadim J. Mottaghy, Felix M. Bartenstein, Peter Tonn, Jörg C. Langen, Karl-Josef |
author_sort | Filss, Christian P. |
collection | PubMed |
description | BACKGROUND: PET using O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological differences between two centres for tumour characterization with (18)F-FET PET using the same PET scanner. Methodological differences between centres A and B in the evaluation of (18)F-FET PET data were identified for (1) framing of PET dynamic data, (2) data reconstruction, (3) cut-off values for tumour delineation to determine tumour-to-brain ratios (TBR) and tumour volume (T(vol)) and (4) ROI definition to determine time activity curves (TACs) in the tumour. Based on the (18)F-FET PET data of 40 patients with untreated cerebral gliomas (20 WHO grade II, 10 WHO grade III, 10 WHO grade IV), the effect of different data processing in the two centres on TBR(mean), TBR(max), T(vol), time-to-peak (TTP) and slope of the TAC was compared. Further, the effect on tumour grading was evaluated by ROC analysis. RESULTS: Significant differences between centres A and B were found especially for TBR(max) (2.84 ± 0.99 versus 3.34 ± 1.13; p < 0.001), T(vol) (1.14 ± 1.28 versus 1.51 ± 1.44; p < 0.001) and TTP (22.4 ± 8.3 min versus 30.8 ± 6.3 min; p < 0.001) and minor differences for TBR(mean) and slope. Tumour grading was not influenced by different data processing. CONCLUSIONS: Variable data processing of (18)F-FET PET in different centres leads to significant differences especially for TBR(max) and T(vol). A standardization of data processing and evaluation is needed to make (18)F-FET PET comparable between different centres. |
format | Online Article Text |
id | pubmed-5559408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-55594082017-09-18 O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres Filss, Christian P. Albert, Nathalie L. Böning, Guido Kops, Elena Rota Suchorska, Bogdana Stoffels, Gabriele Galldiks, Norbert Shah, Nadim J. Mottaghy, Felix M. Bartenstein, Peter Tonn, Jörg C. Langen, Karl-Josef EJNMMI Res Original Research BACKGROUND: PET using O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological differences between two centres for tumour characterization with (18)F-FET PET using the same PET scanner. Methodological differences between centres A and B in the evaluation of (18)F-FET PET data were identified for (1) framing of PET dynamic data, (2) data reconstruction, (3) cut-off values for tumour delineation to determine tumour-to-brain ratios (TBR) and tumour volume (T(vol)) and (4) ROI definition to determine time activity curves (TACs) in the tumour. Based on the (18)F-FET PET data of 40 patients with untreated cerebral gliomas (20 WHO grade II, 10 WHO grade III, 10 WHO grade IV), the effect of different data processing in the two centres on TBR(mean), TBR(max), T(vol), time-to-peak (TTP) and slope of the TAC was compared. Further, the effect on tumour grading was evaluated by ROC analysis. RESULTS: Significant differences between centres A and B were found especially for TBR(max) (2.84 ± 0.99 versus 3.34 ± 1.13; p < 0.001), T(vol) (1.14 ± 1.28 versus 1.51 ± 1.44; p < 0.001) and TTP (22.4 ± 8.3 min versus 30.8 ± 6.3 min; p < 0.001) and minor differences for TBR(mean) and slope. Tumour grading was not influenced by different data processing. CONCLUSIONS: Variable data processing of (18)F-FET PET in different centres leads to significant differences especially for TBR(max) and T(vol). A standardization of data processing and evaluation is needed to make (18)F-FET PET comparable between different centres. Springer Berlin Heidelberg 2017-08-16 /pmc/articles/PMC5559408/ /pubmed/28815478 http://dx.doi.org/10.1186/s13550-017-0316-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Filss, Christian P. Albert, Nathalie L. Böning, Guido Kops, Elena Rota Suchorska, Bogdana Stoffels, Gabriele Galldiks, Norbert Shah, Nadim J. Mottaghy, Felix M. Bartenstein, Peter Tonn, Jörg C. Langen, Karl-Josef O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title | O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title_full | O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title_fullStr | O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title_full_unstemmed | O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title_short | O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres |
title_sort | o-(2-[(18)f]fluoroethyl)-l-tyrosine pet in gliomas: influence of data processing in different centres |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559408/ https://www.ncbi.nlm.nih.gov/pubmed/28815478 http://dx.doi.org/10.1186/s13550-017-0316-x |
work_keys_str_mv | AT filsschristianp o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT albertnathaliel o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT boningguido o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT kopselenarota o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT suchorskabogdana o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT stoffelsgabriele o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT galldiksnorbert o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT shahnadimj o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT mottaghyfelixm o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT bartensteinpeter o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT tonnjorgc o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres AT langenkarljosef o218ffluoroethylltyrosinepetingliomasinfluenceofdataprocessingindifferentcentres |