Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts

Pyruvate dehydrogenase kinase (PDK) is known as a gatekeeper directing the carbon flux into glycolysis via inhibition of the pyruvate dehydrogenase complex. During syncytialization of placental trophoblasts, both ATP production and oxygen consumption are increased to meet enhanced energetic demands...

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Detalles Bibliográficos
Autores principales: Liu, Xiaohui, Zuo, Rujuan, Bao, Yirong, Qu, Xiaoxian, Sun, Kang, Ying, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559526/
https://www.ncbi.nlm.nih.gov/pubmed/28814762
http://dx.doi.org/10.1038/s41598-017-09163-8

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