Cargando…

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adeniran, Ismail, Whittaker, Dominic G., El Harchi, Aziza, Hancox, Jules C., Zhang, Henggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559555/ https://www.ncbi.nlm.nih.gov/pubmed/28814790 http://dx.doi.org/10.1038/s41598-017-08367-2

Ejemplares similares

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria
por: Whittaker, Dominic G., et al.
Publicado: (2017)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling
por: Adeniran, Ismail, et al.
Publicado: (2013)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome
por: Whittaker, Dominic G., et al.
Publicado: (2019)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling
por: Whittaker, Dominic G., et al.
Publicado: (2018)

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K(+) Channel
por: El Harchi, Aziza, et al.
Publicado: (2012)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
por: El Harchi, Aziza, et al.
Publicado: (2009)

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome
por: Adeniran, Ismail, et al.
Publicado: (2011)

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles
por: Whittaker, Dominic G., et al.
Publicado: (2017)

Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition
por: Du, Chunyun, et al.
Publicado: (2013)

Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG ‘hotspot’ mutation
por: Du, Chunyun, et al.
Publicado: (2022)

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp
por: Du, Chunyun, et al.
Publicado: (2022)

Pharmacological activation of the hERG K(+) channel for the management of the long QT syndrome: A review
por: El Harchi, Aziza, et al.
Publicado: (2022)

A novel variant in KCNQ1 associated with short QT syndrome
por: Schneider, Kristin, et al.
Publicado: (2021)

In silico investigation of pro-arrhythmic effects of azithromycin on the human ventricle
por: Liu, Yizhou, et al.
Publicado: (2021)

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome
por: Butler, Andrew, et al.
Publicado: (2019)

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome
por: Butler, Andrew, et al.
Publicado: (2018)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
por: Zhang, Yihong, et al.
Publicado: (2016)

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study
por: Adeniran, Ismail, et al.
Publicado: (2015)

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles
por: Luo, Cunjin, et al.
Publicado: (2017)

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration
por: Melgari, Dario, et al.
Publicado: (2014)

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants
por: Du, Chunyun, et al.
Publicado: (2014)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
por: Melgari, Dario, et al.
Publicado: (2015)

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine
por: El Harchi, Aziza, et al.
Publicado: (2020)

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency
por: Hanington, Oliver P., et al.
Publicado: (2023)

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
por: Helliwell, Matthew V., et al.
Publicado: (2023)

Characterization of a Chinese KCNQ1 mutation (R259H) that shortens repolarization and causes short QT syndrome 2
por: Wu, Zhi-Juan, et al.
Publicado: (2015)

Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome
por: Luo, Cunjin, et al.
Publicado: (2017)

Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome
por: Hancox, J. C., et al.
Publicado: (2023)

Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker
por: Helliwell, Matthew V., et al.
Publicado: (2018)

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations
por: Huang, Hui, et al.
Publicado: (2018)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics – Insights from a 3D Model of the Human Atria
por: Adeniran, Ismail, et al.
Publicado: (2015)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node
por: Zhang, Henggui, et al.
Publicado: (2012)

Short QT and atrial fibrillation: A KCNQ1 mutation–specific disease. Late follow-up in three unrelated children
por: Sarquella-Brugada, Georgia, et al.
Publicado: (2015)

Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study
por: Luo, Cunjin, et al.
Publicado: (2017)

Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling
por: Lee, Hsiang-Chun, et al.
Publicado: (2017)

QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine
por: Malone, Katie, et al.
Publicado: (2020)

The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome
por: Huttunen, Heta, et al.
Publicado: (2018)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy
por: Gysel, Michael, et al.
Publicado: (2014)

Atypical long QT syndrome phenotype in heterozygous/homozygous KCNQ1 Ala590Thr
por: Smith, Justin D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qo6oss2308mr2va4qr02jvdi26