Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

Resistance towards VEGF-centered anti-angiogenic therapy still represents a substantial clinical challenge. We report here that mast cells alter the proliferative and organizational state of endothelial cells which reduces the efficacy of anti-angiogenic therapy. Consequently, absence of mast cells...

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Detalles Bibliográficos
Autores principales: Wroblewski, M., Bauer, R., Cubas Córdova, M., Udonta, F., Ben-Batalla, I., Legler, K., Hauser, C., Egberts, J., Janning, M., Velthaus, J., Schulze, C., Pantel, K., Bokemeyer, C., Loges, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559596/
https://www.ncbi.nlm.nih.gov/pubmed/28814715
http://dx.doi.org/10.1038/s41467-017-00327-8

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