Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

The immune system plays a major role in human health and disease, and understanding genetic causes of interindividual variability of immune responses is vital. Here, we isolate monocytes from 134 genotyped individuals, stimulate these cells with three defined microbe-associated molecular patterns (L...

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Detalles Bibliográficos
Autores principales: Kim-Hellmuth, Sarah, Bechheim, Matthias, Pütz, Benno, Mohammadi, Pejman, Nédélec, Yohann, Giangreco, Nicholas, Becker, Jessica, Kaiser, Vera, Fricker, Nadine, Beier, Esther, Boor, Peter, Castel, Stephane E., Nöthen, Markus M., Barreiro, Luis B., Pickrell, Joseph K., Müller-Myhsok, Bertram, Lappalainen, Tuuli, Schumacher, Johannes, Hornung, Veit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559603/
https://www.ncbi.nlm.nih.gov/pubmed/28814792
http://dx.doi.org/10.1038/s41467-017-00366-1

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