Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

Functional impairments or trafficking defects of inhibitory glycine receptors (GlyRs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders. We found that a lack of synaptic integration of GlyRs, together with disrupted receptor function, is responsible for a lethal s...

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Detalles Bibliográficos
Autores principales: Schaefer, Natascha, Berger, Alexandra, van Brederode, Johannes, Zheng, Fang, Zhang, Yan, Leacock, Sophie, Littau, Laura, Jablonka, Sibylle, Malhotra, Sony, Topf, Maya, Winter, Friederike, Davydova, Daria, Lynch, Joseph W., Paige, Christopher J., Alzheimer, Christian, Harvey, Robert J., Villmann, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559766/
https://www.ncbi.nlm.nih.gov/pubmed/28724750
http://dx.doi.org/10.1523/JNEUROSCI.0009-17.2017

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