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Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes
AIMS: To assess whether circulating 25-hydroxyvitamin D(3) (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in pa...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559910/ https://www.ncbi.nlm.nih.gov/pubmed/28840128 http://dx.doi.org/10.1155/2017/3498368 |
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author | Ramírez-Morros, Anna Granado-Casas, Minerva Alcubierre, Nuria Martinez-Alonso, Montserrat Real, Jordi Castelblanco, Esmeralda Esquerda, Aureli Cao, Gonzalo Rubinat, Esther Hernández, Marta Alonso, Núria Fernández, Elvira Mauricio, Didac |
author_facet | Ramírez-Morros, Anna Granado-Casas, Minerva Alcubierre, Nuria Martinez-Alonso, Montserrat Real, Jordi Castelblanco, Esmeralda Esquerda, Aureli Cao, Gonzalo Rubinat, Esther Hernández, Marta Alonso, Núria Fernández, Elvira Mauricio, Didac |
author_sort | Ramírez-Morros, Anna |
collection | PubMed |
description | AIMS: To assess whether circulating 25-hydroxyvitamin D(3) (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. METHODS: We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained. RESULTS: We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg(2)/dL(2)) product was positively associated with the presence of carotid plaques (OR(adj) = 1.078; 95% CI: 1.017–1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) (β(adj) ± SE = −0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM. |
format | Online Article Text |
id | pubmed-5559910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55599102017-08-24 Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes Ramírez-Morros, Anna Granado-Casas, Minerva Alcubierre, Nuria Martinez-Alonso, Montserrat Real, Jordi Castelblanco, Esmeralda Esquerda, Aureli Cao, Gonzalo Rubinat, Esther Hernández, Marta Alonso, Núria Fernández, Elvira Mauricio, Didac J Diabetes Res Research Article AIMS: To assess whether circulating 25-hydroxyvitamin D(3) (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. METHODS: We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained. RESULTS: We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg(2)/dL(2)) product was positively associated with the presence of carotid plaques (OR(adj) = 1.078; 95% CI: 1.017–1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) (β(adj) ± SE = −0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM. Hindawi 2017 2017-08-03 /pmc/articles/PMC5559910/ /pubmed/28840128 http://dx.doi.org/10.1155/2017/3498368 Text en Copyright © 2017 Anna Ramírez-Morros et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ramírez-Morros, Anna Granado-Casas, Minerva Alcubierre, Nuria Martinez-Alonso, Montserrat Real, Jordi Castelblanco, Esmeralda Esquerda, Aureli Cao, Gonzalo Rubinat, Esther Hernández, Marta Alonso, Núria Fernández, Elvira Mauricio, Didac Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title | Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title_full | Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title_fullStr | Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title_full_unstemmed | Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title_short | Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes |
title_sort | calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559910/ https://www.ncbi.nlm.nih.gov/pubmed/28840128 http://dx.doi.org/10.1155/2017/3498368 |
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