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Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore
OBJECTIVE: The success of oral adjuvant endocrine therapy (OAET) is greatly influenced by patients’ level of adherence to treatment. The objective of this study is to measure the prevalence and determinants of adherence to OAET among breast cancer patients in Singapore. METHODS: A cross-sectional su...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559937/ https://www.ncbi.nlm.nih.gov/pubmed/28966955 http://dx.doi.org/10.4103/2347-5625.212864 |
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author | Ali, Eskinder Eshetu Cheung, Ka Lok Lee, Chee Ping Leow, Jo Lene Yap, Kevin Yi-Lwern Chew, Lita |
author_facet | Ali, Eskinder Eshetu Cheung, Ka Lok Lee, Chee Ping Leow, Jo Lene Yap, Kevin Yi-Lwern Chew, Lita |
author_sort | Ali, Eskinder Eshetu |
collection | PubMed |
description | OBJECTIVE: The success of oral adjuvant endocrine therapy (OAET) is greatly influenced by patients’ level of adherence to treatment. The objective of this study is to measure the prevalence and determinants of adherence to OAET among breast cancer patients in Singapore. METHODS: A cross-sectional survey of patients supplemented by analysis of their prescription records was used to collect data. Adherence to OAET was assessed using the Morisky Medication Adherence Scale-4 items and evaluation of refill gaps. Univariate and multivariate analyses were done to evaluate the association between patients’ characteristics and adherence to OAET. RESULTS: A total of 157 women who have started OAET at least 6 months before the time of interview participated in the study, of which less than half (64 patients, 40.8%) of the patients had high adherence. Univariate analysis identified patients who were 57 years or older (P = 0.027), unemployed (P = 0.027), on aromatase inhibitors (P = 0.023), on three or more concurrent medications (P = 0.001), and had one or more comorbidities (P = 0.000) to be significantly more adherent. However, only the number of comorbidities was found to be an independent predictor of adherence in a multiple logistic regression analysis (adjusted odds ratio = 2.60; 95% confidence interval = 1.208–5.593; P = 0.015). Forgetfulness was the main reason for nonadherence mentioned by 63 (67.7%) of the 93 nonadherent patients. CONCLUSIONS: Low level of OAET adherence was found in this study, and forgetfulness was cited as the main reason for nonadherence. Patients were generally receptive to the implementation of various strategies to assist them with their medication-taking behavior |
format | Online Article Text |
id | pubmed-5559937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55599372017-10-01 Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore Ali, Eskinder Eshetu Cheung, Ka Lok Lee, Chee Ping Leow, Jo Lene Yap, Kevin Yi-Lwern Chew, Lita Asia Pac J Oncol Nurs Original Article OBJECTIVE: The success of oral adjuvant endocrine therapy (OAET) is greatly influenced by patients’ level of adherence to treatment. The objective of this study is to measure the prevalence and determinants of adherence to OAET among breast cancer patients in Singapore. METHODS: A cross-sectional survey of patients supplemented by analysis of their prescription records was used to collect data. Adherence to OAET was assessed using the Morisky Medication Adherence Scale-4 items and evaluation of refill gaps. Univariate and multivariate analyses were done to evaluate the association between patients’ characteristics and adherence to OAET. RESULTS: A total of 157 women who have started OAET at least 6 months before the time of interview participated in the study, of which less than half (64 patients, 40.8%) of the patients had high adherence. Univariate analysis identified patients who were 57 years or older (P = 0.027), unemployed (P = 0.027), on aromatase inhibitors (P = 0.023), on three or more concurrent medications (P = 0.001), and had one or more comorbidities (P = 0.000) to be significantly more adherent. However, only the number of comorbidities was found to be an independent predictor of adherence in a multiple logistic regression analysis (adjusted odds ratio = 2.60; 95% confidence interval = 1.208–5.593; P = 0.015). Forgetfulness was the main reason for nonadherence mentioned by 63 (67.7%) of the 93 nonadherent patients. CONCLUSIONS: Low level of OAET adherence was found in this study, and forgetfulness was cited as the main reason for nonadherence. Patients were generally receptive to the implementation of various strategies to assist them with their medication-taking behavior Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5559937/ /pubmed/28966955 http://dx.doi.org/10.4103/2347-5625.212864 Text en Copyright: © 2017 Ann & Joshua Medical Publishing Co. Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ali, Eskinder Eshetu Cheung, Ka Lok Lee, Chee Ping Leow, Jo Lene Yap, Kevin Yi-Lwern Chew, Lita Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title | Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title_full | Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title_fullStr | Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title_full_unstemmed | Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title_short | Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore |
title_sort | prevalence and determinants of adherence to oral adjuvant endocrine therapy among breast cancer patients in singapore |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559937/ https://www.ncbi.nlm.nih.gov/pubmed/28966955 http://dx.doi.org/10.4103/2347-5625.212864 |
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