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Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption
BACKGROUND: Urinary Ethyl glucuronide (EtG) and Ethyl sulfate (EtS) are established markers of alcohol conumption. Measurement of these markers in serum offers certain advantages. This outpatient department based study evaluated performance of serum Ethyl glucuronide (EtG) and Ethyl sulphate (EtS) a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559998/ https://www.ncbi.nlm.nih.gov/pubmed/28852244 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_71_17 |
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author | Shukla, Lekhansh Sharma, Priyamvada Ganesha, Suhas Ghadigaonkar, Deepak Thomas, Evan Kandasamy, Arun Murthy, Pratima Benegal, Vivek |
author_facet | Shukla, Lekhansh Sharma, Priyamvada Ganesha, Suhas Ghadigaonkar, Deepak Thomas, Evan Kandasamy, Arun Murthy, Pratima Benegal, Vivek |
author_sort | Shukla, Lekhansh |
collection | PubMed |
description | BACKGROUND: Urinary Ethyl glucuronide (EtG) and Ethyl sulfate (EtS) are established markers of alcohol conumption. Measurement of these markers in serum offers certain advantages. This outpatient department based study evaluated performance of serum Ethyl glucuronide (EtG) and Ethyl sulphate (EtS) as biomarkers of recent alcohol consumption in alcohol dependent subjects. It also evaluated effect of alcohol dose and time since consumption on serum EtG and EtS concentration. METHODS: Information regarding alcohol intake was collected using Time line follow back calendar method from 152 subjects. Blood samples were collected to determine serum EtG and EtS concentration. RESULTS: The results revealed that serum EtG (at a threshold of 45 ng/mL) could detect recent moderate to heavy alcohol consumption with 85 percent sensitivity and 89 percent specificity. The results also show that simultaneous measurement of EtS does not increase test accuracy. We found that dose of alcohol and time since alcohol consumption explain 68 and 62 percent variance in serum EtG and EtS levels. CONCLUSION: EtG testing in blood was found useful as a way to detect recent drinking. This sensitive and specific short-term biomarker provides valuable information about recent alcohol consumption. |
format | Online Article Text |
id | pubmed-5559998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55599982017-08-29 Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption Shukla, Lekhansh Sharma, Priyamvada Ganesha, Suhas Ghadigaonkar, Deepak Thomas, Evan Kandasamy, Arun Murthy, Pratima Benegal, Vivek Indian J Psychol Med Original Article BACKGROUND: Urinary Ethyl glucuronide (EtG) and Ethyl sulfate (EtS) are established markers of alcohol conumption. Measurement of these markers in serum offers certain advantages. This outpatient department based study evaluated performance of serum Ethyl glucuronide (EtG) and Ethyl sulphate (EtS) as biomarkers of recent alcohol consumption in alcohol dependent subjects. It also evaluated effect of alcohol dose and time since consumption on serum EtG and EtS concentration. METHODS: Information regarding alcohol intake was collected using Time line follow back calendar method from 152 subjects. Blood samples were collected to determine serum EtG and EtS concentration. RESULTS: The results revealed that serum EtG (at a threshold of 45 ng/mL) could detect recent moderate to heavy alcohol consumption with 85 percent sensitivity and 89 percent specificity. The results also show that simultaneous measurement of EtS does not increase test accuracy. We found that dose of alcohol and time since alcohol consumption explain 68 and 62 percent variance in serum EtG and EtS levels. CONCLUSION: EtG testing in blood was found useful as a way to detect recent drinking. This sensitive and specific short-term biomarker provides valuable information about recent alcohol consumption. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5559998/ /pubmed/28852244 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_71_17 Text en Copyright: © 2017 Indian Psychiatric Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Shukla, Lekhansh Sharma, Priyamvada Ganesha, Suhas Ghadigaonkar, Deepak Thomas, Evan Kandasamy, Arun Murthy, Pratima Benegal, Vivek Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title | Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title_full | Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title_fullStr | Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title_full_unstemmed | Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title_short | Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption |
title_sort | value of ethyl glucuronide and ethyl sulfate in serum as biomarkers of alcohol consumption |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559998/ https://www.ncbi.nlm.nih.gov/pubmed/28852244 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_71_17 |
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