Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick

A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3(rd) episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a r...

Descripción completa

Detalles Bibliográficos
Autores principales: Modak, Tamonud, Kumar, Saurabh, Pal, Arghya, Gupta, Rishab, Pattanayak, Raman Deep, Khandelwal, Sudhir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560013/
https://www.ncbi.nlm.nih.gov/pubmed/28852259
http://dx.doi.org/10.4103/0253-7176.211759
_version_ 1783257624367595520
author Modak, Tamonud
Kumar, Saurabh
Pal, Arghya
Gupta, Rishab
Pattanayak, Raman Deep
Khandelwal, Sudhir Kumar
author_facet Modak, Tamonud
Kumar, Saurabh
Pal, Arghya
Gupta, Rishab
Pattanayak, Raman Deep
Khandelwal, Sudhir Kumar
author_sort Modak, Tamonud
collection PubMed
description A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3(rd) episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed.
format Online
Article
Text
id pubmed-5560013
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-55600132017-08-29 Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick Modak, Tamonud Kumar, Saurabh Pal, Arghya Gupta, Rishab Pattanayak, Raman Deep Khandelwal, Sudhir Kumar Indian J Psychol Med Case Report A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3(rd) episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5560013/ /pubmed/28852259 http://dx.doi.org/10.4103/0253-7176.211759 Text en Copyright: © 2017 Indian Psychiatric Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Modak, Tamonud
Kumar, Saurabh
Pal, Arghya
Gupta, Rishab
Pattanayak, Raman Deep
Khandelwal, Sudhir Kumar
Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title_full Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title_fullStr Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title_full_unstemmed Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title_short Chlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
title_sort chlorpromazine as prophylaxis for bipolar disorder with treatment- and electroconvulsive therapy-refractory mania: old horse, new trick
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560013/
https://www.ncbi.nlm.nih.gov/pubmed/28852259
http://dx.doi.org/10.4103/0253-7176.211759
work_keys_str_mv AT modaktamonud chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick
AT kumarsaurabh chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick
AT palarghya chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick
AT guptarishab chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick
AT pattanayakramandeep chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick
AT khandelwalsudhirkumar chlorpromazineasprophylaxisforbipolardisorderwithtreatmentandelectroconvulsivetherapyrefractorymaniaoldhorsenewtrick

Ejemplares similares