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Epigenetic resetting of human pluripotency

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a more naïve developmental status. Here we provide a method for resetting via transient histone deacetylase inhibition. The protocol is effective across multiple PSC lines and can proceed without karyotype change...

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Detalles Bibliográficos
Autores principales:	Guo, Ge, von Meyenn, Ferdinand, Rostovskaya, Maria, Clarke, James, Dietmann, Sabine, Baker, Duncan, Sahakyan, Anna, Myers, Samuel, Bertone, Paul, Reik, Wolf, Plath, Kathrin, Smith, Austin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2017
Materias:	Stem Cells and Regeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560041/ https://www.ncbi.nlm.nih.gov/pubmed/28765214 http://dx.doi.org/10.1242/dev.146811

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