Kmt1e regulates a large neuron-specific topological chromatin domain

We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Kmt1e/Setdb1 histone H3-lysine 9 methyltransferase, including a large topologically associated 1.2Mb domain conserved in human and mouse and encompassing >70 genes at the cluste...

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Detalles Bibliográficos
Autores principales: Jiang, Yan, Loh, Yong-Hwee Eddie, Rajarajan, Prashanth, Hirayama, Teruyoshi, Liao, Will, Kassim, Bibi S., Javidfar, Behnam, Hartley, Brigham J, Kleofas, Lisa, Park, Royce B, Labonte, Benoit, Ho, Seok-Man, Chandrasekaran, Sandhya, Do, Catherine, Ramirez, Brianna R, Peter, Cyril J., Julia, TCW, Safaie, Brian M, Morishita, Hirofumi, Roussos, Panos, Nestler, Eric J, Schaefer, Anne, Tycko, Benjamin, Brennand, Kristen J, Yagi, Takeshi, Shen, Li, Akbarian, Schahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560095/
https://www.ncbi.nlm.nih.gov/pubmed/28671686
http://dx.doi.org/10.1038/ng.3906

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