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Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling
The close interaction between tumor cells and bone marrow stromal cells plays a crucial role in the tumorigenesis of multiple myeloma (MM). Reelin, an extracellular matrix protein, is found expressed in myeloma cells and is negatively associated with prognosis. We examined the role of Reelin in myel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560138/ https://www.ncbi.nlm.nih.gov/pubmed/28819423 http://dx.doi.org/10.7150/jca.18808 |
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author | Lin, Liang Zhang, Xinwei Cao, Li An, Quanming Hao, Jie Zhang, Yan Jin, Rong Chang, Yingjun Huang, Xiaojun Lu, Jin Ge, Qing |
author_facet | Lin, Liang Zhang, Xinwei Cao, Li An, Quanming Hao, Jie Zhang, Yan Jin, Rong Chang, Yingjun Huang, Xiaojun Lu, Jin Ge, Qing |
author_sort | Lin, Liang |
collection | PubMed |
description | The close interaction between tumor cells and bone marrow stromal cells plays a crucial role in the tumorigenesis of multiple myeloma (MM). Reelin, an extracellular matrix protein, is found expressed in myeloma cells and is negatively associated with prognosis. We examined the role of Reelin in myeloma cell adhesion to bone marrow stromal cells and the signaling pathways involved. The results revealed that Reelin promoted the adhesion of myeloma cells to HS-5, a bone marrow stromal cell line, via the activation of β1 integrin. The resulting phosphorylation of focal adhesion kinase (FAK) led to the activation of Syk/STAT3 and Akt. Reelin's high affinity receptor ApoER2 indirectly modulated the adhesion of myeloma cells by promoting Reelin expression via Sp1. These findings indicate an important role for Reelin/integrin-β1-induced myeloma cell adhesion to bone marrow stromal cells and highlight the therapeutic potential of targeting Reelin/integrin/FAK axis. |
format | Online Article Text |
id | pubmed-5560138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-55601382017-08-17 Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling Lin, Liang Zhang, Xinwei Cao, Li An, Quanming Hao, Jie Zhang, Yan Jin, Rong Chang, Yingjun Huang, Xiaojun Lu, Jin Ge, Qing J Cancer Research Paper The close interaction between tumor cells and bone marrow stromal cells plays a crucial role in the tumorigenesis of multiple myeloma (MM). Reelin, an extracellular matrix protein, is found expressed in myeloma cells and is negatively associated with prognosis. We examined the role of Reelin in myeloma cell adhesion to bone marrow stromal cells and the signaling pathways involved. The results revealed that Reelin promoted the adhesion of myeloma cells to HS-5, a bone marrow stromal cell line, via the activation of β1 integrin. The resulting phosphorylation of focal adhesion kinase (FAK) led to the activation of Syk/STAT3 and Akt. Reelin's high affinity receptor ApoER2 indirectly modulated the adhesion of myeloma cells by promoting Reelin expression via Sp1. These findings indicate an important role for Reelin/integrin-β1-induced myeloma cell adhesion to bone marrow stromal cells and highlight the therapeutic potential of targeting Reelin/integrin/FAK axis. Ivyspring International Publisher 2017-07-15 /pmc/articles/PMC5560138/ /pubmed/28819423 http://dx.doi.org/10.7150/jca.18808 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Lin, Liang Zhang, Xinwei Cao, Li An, Quanming Hao, Jie Zhang, Yan Jin, Rong Chang, Yingjun Huang, Xiaojun Lu, Jin Ge, Qing Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title | Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title_full | Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title_fullStr | Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title_full_unstemmed | Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title_short | Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
title_sort | reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560138/ https://www.ncbi.nlm.nih.gov/pubmed/28819423 http://dx.doi.org/10.7150/jca.18808 |
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