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Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance
Derlin-1 is over-expressed to function as an oncoprotein in breast, lung and colon cancers. However, the implications of Derlin-1 involved in squamous cell carcinoma of the head and neck (SCCHN) remain unknown. This study aims to investigate the effects of Derlin-1 expression on SCCHN tissues and ce...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560153/ https://www.ncbi.nlm.nih.gov/pubmed/28819438 http://dx.doi.org/10.7150/jca.19411 |
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author | Pi, Leiming Zhu, Gangcai She, Li Wei, Ming Liu, Guancheng Chen, Changhan Hu, Di Peng, Fusen Tan, Haolei Liu, Yong Huang, Donghai Tian, Yongquan Zhang, Xin |
author_facet | Pi, Leiming Zhu, Gangcai She, Li Wei, Ming Liu, Guancheng Chen, Changhan Hu, Di Peng, Fusen Tan, Haolei Liu, Yong Huang, Donghai Tian, Yongquan Zhang, Xin |
author_sort | Pi, Leiming |
collection | PubMed |
description | Derlin-1 is over-expressed to function as an oncoprotein in breast, lung and colon cancers. However, the implications of Derlin-1 involved in squamous cell carcinoma of the head and neck (SCCHN) remain unknown. This study aims to investigate the effects of Derlin-1 expression on SCCHN tissues and cells. The potential mechanism of Derlin-1 regulating SCCHN cell proliferation, apoptosis and metastasis was also indicated in this work. Western blot and immunohistochemistry (IHC) assays showed that Derlin-1 was over-expressed in 114 SCCHN samples and five SCCHN cell lines. We found that the expression of Derlin-1 was positively associated with lymph node metastasis, clinical stage and recurrence in our SCCHN patients' samples. Survival analysis indicated that high expression of Derlin-1 was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Knock down expression of Derlin-1 in SCCHN cell lines was found to inhibit cell proliferation, metastasis and promote cell apoptosis. Further experiments showed that signals of PI3K/Akt, p53 and Smad2/3 may involve in these processes. In all, Derlin-1 might be a novel prognostic marker of SCCHN patients and plays an oncogenic role in SCCHN cell progression. |
format | Online Article Text |
id | pubmed-5560153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-55601532017-08-17 Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance Pi, Leiming Zhu, Gangcai She, Li Wei, Ming Liu, Guancheng Chen, Changhan Hu, Di Peng, Fusen Tan, Haolei Liu, Yong Huang, Donghai Tian, Yongquan Zhang, Xin J Cancer Research Paper Derlin-1 is over-expressed to function as an oncoprotein in breast, lung and colon cancers. However, the implications of Derlin-1 involved in squamous cell carcinoma of the head and neck (SCCHN) remain unknown. This study aims to investigate the effects of Derlin-1 expression on SCCHN tissues and cells. The potential mechanism of Derlin-1 regulating SCCHN cell proliferation, apoptosis and metastasis was also indicated in this work. Western blot and immunohistochemistry (IHC) assays showed that Derlin-1 was over-expressed in 114 SCCHN samples and five SCCHN cell lines. We found that the expression of Derlin-1 was positively associated with lymph node metastasis, clinical stage and recurrence in our SCCHN patients' samples. Survival analysis indicated that high expression of Derlin-1 was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Knock down expression of Derlin-1 in SCCHN cell lines was found to inhibit cell proliferation, metastasis and promote cell apoptosis. Further experiments showed that signals of PI3K/Akt, p53 and Smad2/3 may involve in these processes. In all, Derlin-1 might be a novel prognostic marker of SCCHN patients and plays an oncogenic role in SCCHN cell progression. Ivyspring International Publisher 2017-07-21 /pmc/articles/PMC5560153/ /pubmed/28819438 http://dx.doi.org/10.7150/jca.19411 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Pi, Leiming Zhu, Gangcai She, Li Wei, Ming Liu, Guancheng Chen, Changhan Hu, Di Peng, Fusen Tan, Haolei Liu, Yong Huang, Donghai Tian, Yongquan Zhang, Xin Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title | Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title_full | Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title_fullStr | Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title_full_unstemmed | Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title_short | Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
title_sort | elevated expression of derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560153/ https://www.ncbi.nlm.nih.gov/pubmed/28819438 http://dx.doi.org/10.7150/jca.19411 |
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