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Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

INTRODUCTION: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS: Thirty-two LP patients...

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Autores principales: Cemil, Bengu Cevirgen, Yilmazer, Demet, Atas, Hatice, Cengiz, Fatma Pelin, Canpolat, Filiz, Alper, Murat, Gonul, Muzeyyen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560179/
https://www.ncbi.nlm.nih.gov/pubmed/28951706
http://dx.doi.org/10.5114/ada.2017.69311
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author Cemil, Bengu Cevirgen
Yilmazer, Demet
Atas, Hatice
Cengiz, Fatma Pelin
Canpolat, Filiz
Alper, Murat
Gonul, Muzeyyen
author_facet Cemil, Bengu Cevirgen
Yilmazer, Demet
Atas, Hatice
Cengiz, Fatma Pelin
Canpolat, Filiz
Alper, Murat
Gonul, Muzeyyen
author_sort Cemil, Bengu Cevirgen
collection PubMed
description INTRODUCTION: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. RESULTS: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. CONCLUSIONS: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
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spelling pubmed-55601792017-09-26 Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus? Cemil, Bengu Cevirgen Yilmazer, Demet Atas, Hatice Cengiz, Fatma Pelin Canpolat, Filiz Alper, Murat Gonul, Muzeyyen Postepy Dermatol Alergol Original Paper INTRODUCTION: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. RESULTS: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. CONCLUSIONS: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions. Termedia Publishing House 2017-08-01 2017-08 /pmc/articles/PMC5560179/ /pubmed/28951706 http://dx.doi.org/10.5114/ada.2017.69311 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Cemil, Bengu Cevirgen
Yilmazer, Demet
Atas, Hatice
Cengiz, Fatma Pelin
Canpolat, Filiz
Alper, Murat
Gonul, Muzeyyen
Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title_full Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title_fullStr Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title_full_unstemmed Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title_short Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
title_sort does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560179/
https://www.ncbi.nlm.nih.gov/pubmed/28951706
http://dx.doi.org/10.5114/ada.2017.69311
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