Proteomic analysis of elevated intraocular pressure with retinal detachment

PURPOSE: To report a case of elevated intraocular pressure with retinal detachment. OBSERVATIONS: Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels...

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Detalles Bibliográficos
Autores principales: Velez, Gabriel, Roybal, C. Nathaniel, Binkley, Elaine, Bassuk, Alexander G., Tsang, Stephen H., Mahajan, Vinit B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560621/
https://www.ncbi.nlm.nih.gov/pubmed/28825049
http://dx.doi.org/10.1016/j.ajoc.2016.12.023
Descripción
Sumario:PURPOSE: To report a case of elevated intraocular pressure with retinal detachment. OBSERVATIONS: Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology. CONCLUSIONS AND IMPORTANCE: Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.

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