Cargando…

snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma

Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Theref...

Descripción completa

Detalles Bibliográficos
Autores principales: Nogueira Jorge, Natasha Andressa, Wajnberg, Gabriel, Ferreira, Carlos Gil, de Sa Carvalho, Benilton, Passetti, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560661/
https://www.ncbi.nlm.nih.gov/pubmed/28817650
http://dx.doi.org/10.1371/journal.pone.0183410
_version_ 1783257698011185152
author Nogueira Jorge, Natasha Andressa
Wajnberg, Gabriel
Ferreira, Carlos Gil
de Sa Carvalho, Benilton
Passetti, Fabio
author_facet Nogueira Jorge, Natasha Andressa
Wajnberg, Gabriel
Ferreira, Carlos Gil
de Sa Carvalho, Benilton
Passetti, Fabio
author_sort Nogueira Jorge, Natasha Andressa
collection PubMed
description Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer.
format Online
Article
Text
id pubmed-5560661
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-55606612017-08-25 snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma Nogueira Jorge, Natasha Andressa Wajnberg, Gabriel Ferreira, Carlos Gil de Sa Carvalho, Benilton Passetti, Fabio PLoS One Research Article Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer. Public Library of Science 2017-08-17 /pmc/articles/PMC5560661/ /pubmed/28817650 http://dx.doi.org/10.1371/journal.pone.0183410 Text en © 2017 Nogueira Jorge et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nogueira Jorge, Natasha Andressa
Wajnberg, Gabriel
Ferreira, Carlos Gil
de Sa Carvalho, Benilton
Passetti, Fabio
snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title_full snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title_fullStr snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title_full_unstemmed snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title_short snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
title_sort snorna and pirna expression levels modified by tobacco use in women with lung adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560661/
https://www.ncbi.nlm.nih.gov/pubmed/28817650
http://dx.doi.org/10.1371/journal.pone.0183410
work_keys_str_mv AT nogueirajorgenatashaandressa snornaandpirnaexpressionlevelsmodifiedbytobaccouseinwomenwithlungadenocarcinoma
AT wajnberggabriel snornaandpirnaexpressionlevelsmodifiedbytobaccouseinwomenwithlungadenocarcinoma
AT ferreiracarlosgil snornaandpirnaexpressionlevelsmodifiedbytobaccouseinwomenwithlungadenocarcinoma
AT desacarvalhobenilton snornaandpirnaexpressionlevelsmodifiedbytobaccouseinwomenwithlungadenocarcinoma
AT passettifabio snornaandpirnaexpressionlevelsmodifiedbytobaccouseinwomenwithlungadenocarcinoma