Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Furthermore, autophagy is induced by the SIRT1-FoxO signaling pathway and was recently shown to be a critical protective mechanism against non-alcoho...

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Detalles Bibliográficos
Autores principales: Ding, Shibin, Jiang, Jinjin, Zhang, Guofu, Bu, Yongjun, Zhang, Guanghui, Zhao, Xiangmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560739/
https://www.ncbi.nlm.nih.gov/pubmed/28817690
http://dx.doi.org/10.1371/journal.pone.0183541

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