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Dynamic role of the tether helix in PIP(2)-dependent gating of a G protein–gated potassium channel

G protein–gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP(2)) is an essential cofactor for GIRK channel gating, but the pr...

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Detalles Bibliográficos
Autores principales:	Lacin, Emre, Aryal, Prafulla, Glaaser, Ian W., Bodhinathan, Karthik, Tsai, Eric, Marsh, Nidaa, Tucker, Stephen J., Sansom, Mark S.P., Slesinger, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560777/ https://www.ncbi.nlm.nih.gov/pubmed/28720589 http://dx.doi.org/10.1085/jgp.201711801

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