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Mechanisms of noncovalent β subunit regulation of Na(V) channel gating

Voltage-gated Na(+) (Na(V)) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applyin...

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Detalles Bibliográficos
Autores principales:	Zhu, Wandi, Voelker, Taylor L., Varga, Zoltan, Schubert, Angela R., Nerbonne, Jeanne M., Silva, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560778/ https://www.ncbi.nlm.nih.gov/pubmed/28720590 http://dx.doi.org/10.1085/jgp.201711802

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