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Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action
Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior boundary forms a concentration gradient that controls the expression domains of target genes, which in turn specify the posi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560859/ https://www.ncbi.nlm.nih.gov/pubmed/28675374 http://dx.doi.org/10.7554/eLife.22546 |
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author | Bosch, Pablo Sanchez Ziukaite, Ruta Alexandre, Cyrille Basler, Konrad Vincent, Jean-Paul |
author_facet | Bosch, Pablo Sanchez Ziukaite, Ruta Alexandre, Cyrille Basler, Konrad Vincent, Jean-Paul |
author_sort | Bosch, Pablo Sanchez |
collection | PubMed |
description | Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior boundary forms a concentration gradient that controls the expression domains of target genes, which in turn specify the position of wing veins. Dpp also promotes growth in this tissue. The relationship between the spatio-temporal profile of Dpp signalling and growth has been the subject of debate, which has intensified recently with the suggestion that the stripe of Dpp is dispensable for growth. With two independent conditional alleles of dpp, we find that the stripe of Dpp is essential for wing growth. We then show that this requirement, but not patterning, can be fulfilled by uniform, low level, Dpp expression. Thus, the stripe of Dpp ensures that signalling remains above a pro-growth threshold, while at the same time generating a gradient that patterns cell fates. DOI: http://dx.doi.org/10.7554/eLife.22546.001 |
format | Online Article Text |
id | pubmed-5560859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55608592017-08-21 Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action Bosch, Pablo Sanchez Ziukaite, Ruta Alexandre, Cyrille Basler, Konrad Vincent, Jean-Paul eLife Cell Biology Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior boundary forms a concentration gradient that controls the expression domains of target genes, which in turn specify the position of wing veins. Dpp also promotes growth in this tissue. The relationship between the spatio-temporal profile of Dpp signalling and growth has been the subject of debate, which has intensified recently with the suggestion that the stripe of Dpp is dispensable for growth. With two independent conditional alleles of dpp, we find that the stripe of Dpp is essential for wing growth. We then show that this requirement, but not patterning, can be fulfilled by uniform, low level, Dpp expression. Thus, the stripe of Dpp ensures that signalling remains above a pro-growth threshold, while at the same time generating a gradient that patterns cell fates. DOI: http://dx.doi.org/10.7554/eLife.22546.001 eLife Sciences Publications, Ltd 2017-07-04 /pmc/articles/PMC5560859/ /pubmed/28675374 http://dx.doi.org/10.7554/eLife.22546 Text en © 2017, Bosch et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Cell Biology Bosch, Pablo Sanchez Ziukaite, Ruta Alexandre, Cyrille Basler, Konrad Vincent, Jean-Paul Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title | Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title_full | Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title_fullStr | Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title_full_unstemmed | Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title_short | Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action |
title_sort | dpp controls growth and patterning in drosophila wing precursors through distinct modes of action |
topic | Cell Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560859/ https://www.ncbi.nlm.nih.gov/pubmed/28675374 http://dx.doi.org/10.7554/eLife.22546 |
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