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Dynamics of genomic innovation in the unicellular ancestry of animals
Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative ana...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560861/ https://www.ncbi.nlm.nih.gov/pubmed/28726632 http://dx.doi.org/10.7554/eLife.26036 |
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author | Grau-Bové, Xavier Torruella, Guifré Donachie, Stuart Suga, Hiroshi Leonard, Guy Richards, Thomas A Ruiz-Trillo, Iñaki |
author_facet | Grau-Bové, Xavier Torruella, Guifré Donachie, Stuart Suga, Hiroshi Leonard, Guy Richards, Thomas A Ruiz-Trillo, Iñaki |
author_sort | Grau-Bové, Xavier |
collection | PubMed |
description | Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here, we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions. Thus, the foundations of animal genome architecture were laid before the origin of complex multicellularity – highlighting the necessity of a unicellular perspective to understand early animal evolution. DOI: http://dx.doi.org/10.7554/eLife.26036.001 |
format | Online Article Text |
id | pubmed-5560861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55608612017-08-21 Dynamics of genomic innovation in the unicellular ancestry of animals Grau-Bové, Xavier Torruella, Guifré Donachie, Stuart Suga, Hiroshi Leonard, Guy Richards, Thomas A Ruiz-Trillo, Iñaki eLife Genes and Chromosomes Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here, we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions. Thus, the foundations of animal genome architecture were laid before the origin of complex multicellularity – highlighting the necessity of a unicellular perspective to understand early animal evolution. DOI: http://dx.doi.org/10.7554/eLife.26036.001 eLife Sciences Publications, Ltd 2017-07-20 /pmc/articles/PMC5560861/ /pubmed/28726632 http://dx.doi.org/10.7554/eLife.26036 Text en © 2017, Grau-Bové et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Genes and Chromosomes Grau-Bové, Xavier Torruella, Guifré Donachie, Stuart Suga, Hiroshi Leonard, Guy Richards, Thomas A Ruiz-Trillo, Iñaki Dynamics of genomic innovation in the unicellular ancestry of animals |
title | Dynamics of genomic innovation in the unicellular ancestry of animals |
title_full | Dynamics of genomic innovation in the unicellular ancestry of animals |
title_fullStr | Dynamics of genomic innovation in the unicellular ancestry of animals |
title_full_unstemmed | Dynamics of genomic innovation in the unicellular ancestry of animals |
title_short | Dynamics of genomic innovation in the unicellular ancestry of animals |
title_sort | dynamics of genomic innovation in the unicellular ancestry of animals |
topic | Genes and Chromosomes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560861/ https://www.ncbi.nlm.nih.gov/pubmed/28726632 http://dx.doi.org/10.7554/eLife.26036 |
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