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Dynamics of genomic innovation in the unicellular ancestry of animals

Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative ana...

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Autores principales: Grau-Bové, Xavier, Torruella, Guifré, Donachie, Stuart, Suga, Hiroshi, Leonard, Guy, Richards, Thomas A, Ruiz-Trillo, Iñaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560861/
https://www.ncbi.nlm.nih.gov/pubmed/28726632
http://dx.doi.org/10.7554/eLife.26036
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author Grau-Bové, Xavier
Torruella, Guifré
Donachie, Stuart
Suga, Hiroshi
Leonard, Guy
Richards, Thomas A
Ruiz-Trillo, Iñaki
author_facet Grau-Bové, Xavier
Torruella, Guifré
Donachie, Stuart
Suga, Hiroshi
Leonard, Guy
Richards, Thomas A
Ruiz-Trillo, Iñaki
author_sort Grau-Bové, Xavier
collection PubMed
description Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here, we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions. Thus, the foundations of animal genome architecture were laid before the origin of complex multicellularity – highlighting the necessity of a unicellular perspective to understand early animal evolution. DOI: http://dx.doi.org/10.7554/eLife.26036.001
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spelling pubmed-55608612017-08-21 Dynamics of genomic innovation in the unicellular ancestry of animals Grau-Bové, Xavier Torruella, Guifré Donachie, Stuart Suga, Hiroshi Leonard, Guy Richards, Thomas A Ruiz-Trillo, Iñaki eLife Genes and Chromosomes Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here, we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions. Thus, the foundations of animal genome architecture were laid before the origin of complex multicellularity – highlighting the necessity of a unicellular perspective to understand early animal evolution. DOI: http://dx.doi.org/10.7554/eLife.26036.001 eLife Sciences Publications, Ltd 2017-07-20 /pmc/articles/PMC5560861/ /pubmed/28726632 http://dx.doi.org/10.7554/eLife.26036 Text en © 2017, Grau-Bové et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genes and Chromosomes
Grau-Bové, Xavier
Torruella, Guifré
Donachie, Stuart
Suga, Hiroshi
Leonard, Guy
Richards, Thomas A
Ruiz-Trillo, Iñaki
Dynamics of genomic innovation in the unicellular ancestry of animals
title Dynamics of genomic innovation in the unicellular ancestry of animals
title_full Dynamics of genomic innovation in the unicellular ancestry of animals
title_fullStr Dynamics of genomic innovation in the unicellular ancestry of animals
title_full_unstemmed Dynamics of genomic innovation in the unicellular ancestry of animals
title_short Dynamics of genomic innovation in the unicellular ancestry of animals
title_sort dynamics of genomic innovation in the unicellular ancestry of animals
topic Genes and Chromosomes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560861/
https://www.ncbi.nlm.nih.gov/pubmed/28726632
http://dx.doi.org/10.7554/eLife.26036
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