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Prevalence and characteristics of resistant hypertensive patients in an Asian population

BACKGROUND: Resistant hypertension is a well-recognized clinical challenge yet there are no reported data on its prevalence in Pakistan. These patients are subjected to a higher risk of developing hypertensive complications. The objective of our study was to evaluate the prevalence and determinants...

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Autores principales: Naseem, Rabia, Adam, Arsalan Majeed, Khan, Fiza, Dossal, Adiya, Khan, Ibrahim, Khan, Ammara, Paul, Hannah, Jawed, Hafsa, Aslam, Aisha, Syed, Faez Muhammad, Niazi, Muhammad Ahsen, Nadeem, Shehzeen, Khan, Aruba, Zia, Amber, Arshad, Mohammad Hussham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560875/
https://www.ncbi.nlm.nih.gov/pubmed/28822508
http://dx.doi.org/10.1016/j.ihj.2017.01.012
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author Naseem, Rabia
Adam, Arsalan Majeed
Khan, Fiza
Dossal, Adiya
Khan, Ibrahim
Khan, Ammara
Paul, Hannah
Jawed, Hafsa
Aslam, Aisha
Syed, Faez Muhammad
Niazi, Muhammad Ahsen
Nadeem, Shehzeen
Khan, Aruba
Zia, Amber
Arshad, Mohammad Hussham
author_facet Naseem, Rabia
Adam, Arsalan Majeed
Khan, Fiza
Dossal, Adiya
Khan, Ibrahim
Khan, Ammara
Paul, Hannah
Jawed, Hafsa
Aslam, Aisha
Syed, Faez Muhammad
Niazi, Muhammad Ahsen
Nadeem, Shehzeen
Khan, Aruba
Zia, Amber
Arshad, Mohammad Hussham
author_sort Naseem, Rabia
collection PubMed
description BACKGROUND: Resistant hypertension is a well-recognized clinical challenge yet there are no reported data on its prevalence in Pakistan. These patients are subjected to a higher risk of developing hypertensive complications. The objective of our study was to evaluate the prevalence and determinants of resistant hypertension in an Asian cohort of hypertensive patients. METHODS: This cross-sectional study was carried out among hypertensive patients visiting a tertiary care hospital in Karachi from September-December 2015. Patient data and characteristics were recorded using a pre-coded questionnaire. Morisky and Berlin questionnaires were used to assess compliance to medications and determine the risk of developing obstructive sleep apnea, respectively. Pearson's chi-square test was used to analyze statistical differences between hypertensive patients and related factors. RESULTS: A total of 515 patients were included in the study. Overall, 12% of the total patients (n = 62) were resistant hypertensives and 25% (n = 129) had pseudo-resistant hypertension. Resistant patients were more often females, older and had a higher body mass index (all P < 0.001). Use of painkillers and noncompliance to dietary recommendations were found to be significant determinants of resistant hypertension. Prevalence of comorbid conditions, including diabetes (p = 0.33), hyperlipidemia (p = 0.46), and chronic kidney disease (p = 0.23), was not significantly higher in patients with resistant hypertension. CONCLUSION: Nearly one in ten hypertensive patients had true resistant hypertension, and twenty-five percent of patients had pseudo-resistance. Resistance hypertensions is significantly associated with female gender, older age, obesity, dietary noncompliance and increased use of NSAIDs.
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spelling pubmed-55608752018-07-01 Prevalence and characteristics of resistant hypertensive patients in an Asian population Naseem, Rabia Adam, Arsalan Majeed Khan, Fiza Dossal, Adiya Khan, Ibrahim Khan, Ammara Paul, Hannah Jawed, Hafsa Aslam, Aisha Syed, Faez Muhammad Niazi, Muhammad Ahsen Nadeem, Shehzeen Khan, Aruba Zia, Amber Arshad, Mohammad Hussham Indian Heart J Original Article BACKGROUND: Resistant hypertension is a well-recognized clinical challenge yet there are no reported data on its prevalence in Pakistan. These patients are subjected to a higher risk of developing hypertensive complications. The objective of our study was to evaluate the prevalence and determinants of resistant hypertension in an Asian cohort of hypertensive patients. METHODS: This cross-sectional study was carried out among hypertensive patients visiting a tertiary care hospital in Karachi from September-December 2015. Patient data and characteristics were recorded using a pre-coded questionnaire. Morisky and Berlin questionnaires were used to assess compliance to medications and determine the risk of developing obstructive sleep apnea, respectively. Pearson's chi-square test was used to analyze statistical differences between hypertensive patients and related factors. RESULTS: A total of 515 patients were included in the study. Overall, 12% of the total patients (n = 62) were resistant hypertensives and 25% (n = 129) had pseudo-resistant hypertension. Resistant patients were more often females, older and had a higher body mass index (all P < 0.001). Use of painkillers and noncompliance to dietary recommendations were found to be significant determinants of resistant hypertension. Prevalence of comorbid conditions, including diabetes (p = 0.33), hyperlipidemia (p = 0.46), and chronic kidney disease (p = 0.23), was not significantly higher in patients with resistant hypertension. CONCLUSION: Nearly one in ten hypertensive patients had true resistant hypertension, and twenty-five percent of patients had pseudo-resistance. Resistance hypertensions is significantly associated with female gender, older age, obesity, dietary noncompliance and increased use of NSAIDs. Elsevier 2017 2017-01-26 /pmc/articles/PMC5560875/ /pubmed/28822508 http://dx.doi.org/10.1016/j.ihj.2017.01.012 Text en © 2017 Published by Elsevier B.V., a division of Reed Elsevier India, Pvt. Ltd on behalf of Cardiological Society of India. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Naseem, Rabia
Adam, Arsalan Majeed
Khan, Fiza
Dossal, Adiya
Khan, Ibrahim
Khan, Ammara
Paul, Hannah
Jawed, Hafsa
Aslam, Aisha
Syed, Faez Muhammad
Niazi, Muhammad Ahsen
Nadeem, Shehzeen
Khan, Aruba
Zia, Amber
Arshad, Mohammad Hussham
Prevalence and characteristics of resistant hypertensive patients in an Asian population
title Prevalence and characteristics of resistant hypertensive patients in an Asian population
title_full Prevalence and characteristics of resistant hypertensive patients in an Asian population
title_fullStr Prevalence and characteristics of resistant hypertensive patients in an Asian population
title_full_unstemmed Prevalence and characteristics of resistant hypertensive patients in an Asian population
title_short Prevalence and characteristics of resistant hypertensive patients in an Asian population
title_sort prevalence and characteristics of resistant hypertensive patients in an asian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560875/
https://www.ncbi.nlm.nih.gov/pubmed/28822508
http://dx.doi.org/10.1016/j.ihj.2017.01.012
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