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Alanine Mutagenesis in the Complementarity Determining Region 3 of the MTB and HIV-1 Peptide-Bispecific T Cell Receptor Beta Chain Affects Ligand Recognition

Mycobacterium tuberculosis/human immunodeficiency virus (MTB/HIV) coinfection presents a special challenge to the prevention and treatment of tuberculosis and HIV/AIDS. Adoptive transfer of high-affinity T cell receptor (TCR) gene-modified T cells against MTB and HIV antigens is a promising approach...

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Detalles Bibliográficos
Autores principales:	Zhou, Chao-Ying, Wang, Rui-Ning, Wen, Qian, He, Wen-Ting, Zhang, Shi-Meng, Du, Xia-Lin, Yang, Jia-Hui, Ma, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561015/ https://www.ncbi.nlm.nih.gov/pubmed/28861087 http://dx.doi.org/10.3389/fimmu.2017.00983

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