Cargando…

EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture

We found that the coagulation and cytokine pathways were important mechanisms involve in the degeneration of intervertebral discs (IVD) using a microarray approach to analyze gene expression in different grades of specimens. Furthermore, using a cytokine/chemokine array, a significant increase in CX...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Bor-Ren, Chen, Tzu-Sheng, Bau, Da-Tian, Chuang, I-Chen, Tsai, Cheng-Fang, Chang, Pei-Chun, Lu, Dah-Yuu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561020/ https://www.ncbi.nlm.nih.gov/pubmed/28819180 http://dx.doi.org/10.1038/s41598-017-09122-3

Ejemplares similares

Pro-Inflammatory Stimuli Influence Expression of Intercellular Adhesion Molecule 1 in Human Anulus Fibrosus Cells through FAK/ERK/GSK3 and PKCδ Signaling Pathways
por: Huang, Bor-Ren, et al.
Publicado: (2018)

A bovine nucleus pulposus explant culture model
por: Salzer, Elias, et al.
Publicado: (2021)

Harmonization and standardization of nucleus pulposus cell extraction and culture methods
por: Basatvat, Shaghayegh, et al.
Publicado: (2023)

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence
por: Li, Xiao-Chuan, et al.
Publicado: (2018)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro
por: Li, Xiaoming, et al.
Publicado: (2019)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Inflammation Induces Irreversible Biophysical Changes in Isolated Nucleus Pulposus Cells
por: Maidhof, Robert, et al.
Publicado: (2014)

CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions
por: Huang, Bor-Ren, et al.
Publicado: (2020)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
por: Sinkemani, Arjun, et al.
Publicado: (2020)

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells
por: Chen, Chang‐chun, et al.
Publicado: (2020)

Surgical removal and controlled trypsinization of the outer annulus fibrosus improves the bioactivity of the nucleus pulposus in a disc bioreactor culture
por: Li, Pei, et al.
Publicado: (2016)

Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells
por: Bai, Xiaoliang, et al.
Publicado: (2019)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
por: Krouwels, Anita, et al.
Publicado: (2020)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Alterations of bovine nucleus pulposus cells with aging
por: Molinos, Maria, et al.
Publicado: (2023)

Standardisation of basal medium for reproducible culture of human annulus fibrosus and nucleus pulposus cells
por: Schubert, Ann-Kathrin, et al.
Publicado: (2018)

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency
por: Guerrero, Julien, et al.
Publicado: (2020)

The combinatory effect of scaffold topography and culture condition: an approach to nucleus pulposus tissue engineering
por: Vanawati, Noviana, et al.
Publicado: (2022)

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration
por: Richardson, Stephen M., et al.
Publicado: (2017)

Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells
por: Liang, Hang, et al.
Publicado: (2018)

Intradural cervical herniated nucleus pulposus presentation and management: a case report
por: Yen, Tzu Chuan, et al.
Publicado: (2023)

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats
por: Lan, Wei-ren, et al.
Publicado: (2019)

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions
por: Hwang, Priscilla Y, et al.
Publicado: (2016)

Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells
por: Chen, Rigao, et al.
Publicado: (2021)

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration
por: Liu, Fan-jie, et al.
Publicado: (2021)

The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration
por: Liu, Chang, et al.
Publicado: (2021)

Regenerative and Immunogenic Characteristics of Cultured Nucleus Pulposus Cells from Human Cervical Intervertebral Discs
por: Stich, Stefan, et al.
Publicado: (2015)

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in an Organ Culture
por: Zhan, Jia-Wen, et al.
Publicado: (2016)

The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture
por: Shi, Jianmin, et al.
Publicado: (2018)

Effect of optimized collagenase digestion on isolated and cultured nucleus pulposus cells in degenerated intervertebral discs
por: Feng, Xu, et al.
Publicado: (2018)

Effects of Oxygen Concentration and Culture Time on Porcine Nucleus Pulposus Cell Metabolism: An in vitro Study
por: Jaworski, Lukas M., et al.
Publicado: (2019)

Development of 2-D and 3-D culture platforms derived from decellularized nucleus pulposus
por: Herrera Quijano, Marco A., et al.
Publicado: (2022)

Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments
por: McDonnell, Emily E., et al.
Publicado: (2022)

Dimethyl fumarate protects nucleus pulposus cells from inflammation and oxidative stress and delays the intervertebral disc degeneration
por: Zhu, Hainian, et al.
Publicado: (2020)

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells
por: Li, Xunlin, et al.
Publicado: (2019)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Transcriptional profiling of the nucleus pulposus: say yes to notochord
por: Shapiro, Irving M, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5ajm4upg54trsfc5dfl761fumm