Cargando…

A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation

This study examined the association of sleep with inflammation and oxidative stress biomarkers, and with functional outcomes, after stroke rehabilitation. The rehabilitation effects on biomarkers and functional outcomes were also evaluated. Twenty subacute stroke survivors received 4 weeks of upper...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeh, Ting-ting, Hsieh, Yu-wei, Wu, Ching-yi, Wang, Jong-shyan, Lin, Keh-chung, Chen, Chia-ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561026/
https://www.ncbi.nlm.nih.gov/pubmed/28819157
http://dx.doi.org/10.1038/s41598-017-08931-w
_version_ 1783257757294526464
author Yeh, Ting-ting
Hsieh, Yu-wei
Wu, Ching-yi
Wang, Jong-shyan
Lin, Keh-chung
Chen, Chia-ling
author_facet Yeh, Ting-ting
Hsieh, Yu-wei
Wu, Ching-yi
Wang, Jong-shyan
Lin, Keh-chung
Chen, Chia-ling
author_sort Yeh, Ting-ting
collection PubMed
description This study examined the association of sleep with inflammation and oxidative stress biomarkers, and with functional outcomes, after stroke rehabilitation. The rehabilitation effects on biomarkers and functional outcomes were also evaluated. Twenty subacute stroke survivors received 4 weeks of upper limb rehabilitation. Baseline inflammatory (i.e., soluble intercellular adhesion molecule-1, sICAM-1) and oxidative stress biomarkers (i.e., glutathione peroxidase, GPx and malondialdehyde, MDA) were assessed, as were sleep outcomes. Positive correlations were observed between baseline level of sICAM-1 and number of awakenings at post-treatment (ρ = 0.51, p < 0.05) as well as between baseline level of MDA and post-performance time of the Wolf Motor Function Test (WMFT-time) (ρ = 0.46, p < 0.05). In addition, MDA levels were significantly decreased, and functional outcomes of the modified Rankin Scale (mRS), functional ability scale of the WMFT, and Stroke Impact Scale (SIS-total, and SIS-physical function) were improved after the rehabilitation. This pilot study emphasizes the relationship among biomarkers, sleep, and functional outcomes after stroke rehabilitation. Oxidative stress markers may be useful predictors of functional outcomes in subacute stroke survivors.
format Online
Article
Text
id pubmed-5561026
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55610262017-08-18 A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation Yeh, Ting-ting Hsieh, Yu-wei Wu, Ching-yi Wang, Jong-shyan Lin, Keh-chung Chen, Chia-ling Sci Rep Article This study examined the association of sleep with inflammation and oxidative stress biomarkers, and with functional outcomes, after stroke rehabilitation. The rehabilitation effects on biomarkers and functional outcomes were also evaluated. Twenty subacute stroke survivors received 4 weeks of upper limb rehabilitation. Baseline inflammatory (i.e., soluble intercellular adhesion molecule-1, sICAM-1) and oxidative stress biomarkers (i.e., glutathione peroxidase, GPx and malondialdehyde, MDA) were assessed, as were sleep outcomes. Positive correlations were observed between baseline level of sICAM-1 and number of awakenings at post-treatment (ρ = 0.51, p < 0.05) as well as between baseline level of MDA and post-performance time of the Wolf Motor Function Test (WMFT-time) (ρ = 0.46, p < 0.05). In addition, MDA levels were significantly decreased, and functional outcomes of the modified Rankin Scale (mRS), functional ability scale of the WMFT, and Stroke Impact Scale (SIS-total, and SIS-physical function) were improved after the rehabilitation. This pilot study emphasizes the relationship among biomarkers, sleep, and functional outcomes after stroke rehabilitation. Oxidative stress markers may be useful predictors of functional outcomes in subacute stroke survivors. Nature Publishing Group UK 2017-08-17 /pmc/articles/PMC5561026/ /pubmed/28819157 http://dx.doi.org/10.1038/s41598-017-08931-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yeh, Ting-ting
Hsieh, Yu-wei
Wu, Ching-yi
Wang, Jong-shyan
Lin, Keh-chung
Chen, Chia-ling
A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title_full A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title_fullStr A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title_full_unstemmed A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title_short A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation
title_sort preliminary investigation of the association of sleep with inflammation and oxidative stress biomarkers and functional outcomes after stroke rehabilitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561026/
https://www.ncbi.nlm.nih.gov/pubmed/28819157
http://dx.doi.org/10.1038/s41598-017-08931-w
work_keys_str_mv AT yehtingting apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT hsiehyuwei apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT wuchingyi apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT wangjongshyan apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT linkehchung apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT chenchialing apreliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT yehtingting preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT hsiehyuwei preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT wuchingyi preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT wangjongshyan preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT linkehchung preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation
AT chenchialing preliminaryinvestigationoftheassociationofsleepwithinflammationandoxidativestressbiomarkersandfunctionaloutcomesafterstrokerehabilitation