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Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase encoded in the nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT possesses two high frequency single nucleotide variants (SNVs), rs11544484 (V256I, Minor Allele Frequency = 0.27) and rs2293925 (R5...

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Detalles Bibliográficos
Autores principales:	Zhang, Hongliang, Seol, Yeonee, Agama, Keli, Neuman, Keir C., Pommier, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561071/ https://www.ncbi.nlm.nih.gov/pubmed/28819183 http://dx.doi.org/10.1038/s41598-017-09258-2

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