Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4...

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Autores principales: Song, Yong-xi, Sun, Jing-xu, Zhao, Jun-hua, Yang, Yu-chong, Shi, Jin-xin, Wu, Zhong-hua, Chen, Xiao-wan, Gao, Peng, Miao, Zhi-feng, Wang, Zhen-ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561086/
https://www.ncbi.nlm.nih.gov/pubmed/28819095
http://dx.doi.org/10.1038/s41467-017-00304-1
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author Song, Yong-xi
Sun, Jing-xu
Zhao, Jun-hua
Yang, Yu-chong
Shi, Jin-xin
Wu, Zhong-hua
Chen, Xiao-wan
Gao, Peng
Miao, Zhi-feng
Wang, Zhen-ning
author_facet Song, Yong-xi
Sun, Jing-xu
Zhao, Jun-hua
Yang, Yu-chong
Shi, Jin-xin
Wu, Zhong-hua
Chen, Xiao-wan
Gao, Peng
Miao, Zhi-feng
Wang, Zhen-ning
author_sort Song, Yong-xi
collection PubMed
description Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.
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spelling pubmed-55610862017-08-28 Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion Song, Yong-xi Sun, Jing-xu Zhao, Jun-hua Yang, Yu-chong Shi, Jin-xin Wu, Zhong-hua Chen, Xiao-wan Gao, Peng Miao, Zhi-feng Wang, Zhen-ning Nat Commun Article Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer. Nature Publishing Group UK 2017-08-18 /pmc/articles/PMC5561086/ /pubmed/28819095 http://dx.doi.org/10.1038/s41467-017-00304-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Song, Yong-xi
Sun, Jing-xu
Zhao, Jun-hua
Yang, Yu-chong
Shi, Jin-xin
Wu, Zhong-hua
Chen, Xiao-wan
Gao, Peng
Miao, Zhi-feng
Wang, Zhen-ning
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title_full Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title_fullStr Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title_full_unstemmed Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title_short Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
title_sort non-coding rnas participate in the regulatory network of cldn4 via cerna mediated mirna evasion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561086/
https://www.ncbi.nlm.nih.gov/pubmed/28819095
http://dx.doi.org/10.1038/s41467-017-00304-1
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