CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function

MicroRNAs (miRNAs) are important regulators of diverse physiological and pathophysiological processes. MiRNA families and clusters are two key features in miRNA biology. Here we explore the use of CRISPR/Cas9 as a powerful tool to delineate the function and regulation of miRNA families and clusters....

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Detalles Bibliográficos
Autores principales: Lataniotis, Lazaros, Albrecht, Andreas, Kok, Fatma O., Monfries, Clinton A. L., Benedetti, Lorena, Lawson, Nathan D., Hughes, Simon M., Steinhofel, Kathleen, Mayr, Manuel, Zampetaki, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561095/
https://www.ncbi.nlm.nih.gov/pubmed/28819307
http://dx.doi.org/10.1038/s41598-017-09268-0

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