Fusion protein analysis reveals the precise regulation between Hsp70 and Hsp100 during protein disaggregation

ClpB, a bacterial Hsp100, is a ring-shaped AAA+ chaperone that can reactivate aggregated proteins in cooperation with DnaK, a bacterial Hsp70, and its co-factors. ClpB subunits comprise two AAA+ modules with an interstitial rod-shaped M-domain. The M-domain regulates ClpB ATPase activity and interac...

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Detalles Bibliográficos
Autores principales: Hayashi, Sayaka, Nakazaki, Yosuke, Kagii, Kei, Imamura, Hiromi, Watanabe, Yo-hei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561102/
https://www.ncbi.nlm.nih.gov/pubmed/28819163
http://dx.doi.org/10.1038/s41598-017-08917-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561102/
https://www.ncbi.nlm.nih.gov/pubmed/28819163
http://dx.doi.org/10.1038/s41598-017-08917-8

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